{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:38:57Z","timestamp":1785893937482,"version":"3.56.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":9757,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1983,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Infection of guinea-pigs by intranasal (i.n.) instillation of 10<jats:sup>9<\/jats:sup>viable organisms of two newly isolated strains of<jats:italic>Legionella pneumophila<\/jats:italic>(74\/81, serogroup 1; 166\/81, serogroup 3) did not induce disease, but 10<jats:sup>4<\/jats:sup>organisms administered as a small particle aerosol (&lt; 5 \u03bcm diameter) produced a fatal widespread bronchopneumonia within 3 days. Milder illness and less extensive bronchopneumonia were also produced in rhesus monkeys and marmosets by one of these two strains (74\/81). Mice were resistant to induction of disease by aerosols of both these two strains, though organisms did persist in the lungs for at least 4 days. Both of these<jats:italic>L. pneumophila<\/jats:italic>strains were pathogenic for guinea-pigs by aerosol infection over a wide range of doses but the serogroup 1 type strain (NCTC 11192) was not. There was no mortality after infection of guinea-pigs by intranasal instillation of any of these strains but all proved to be fatal after intraperitoneal (i.p.) injection of large doses. Guinea-pigs, rhesus monkeys and marmosets exposed to aerosol infection with<jats:italic>L. pneumophila<\/jats:italic>provide relevant models for studying the pathogenesis of Legionnaires' disease.<\/jats:p>","DOI":"10.1017\/s0022172400063877","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T13:03:05Z","timestamp":1255957385000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":79,"title":["Aerosol infection of animals with strains of<i>Legionella pneumophila<\/i>of different virulence: comparison with intraperitoneal and intranasal routes of infection"],"prefix":"10.1017","volume":"90","author":[{"given":"R. B.","family":"Fitzgeorge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Baskerville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Broster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hambleton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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