{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:34:24Z","timestamp":1791196464942,"version":"4.1.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":8419,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To determine the pathogenic potential of the vesiculoviruses Isfahan Chandipura for domestic animals, two ponies, two steers, three and three pigs were inoculated with each virus intradermally in the tongue or, in the case of the pigs, in the snout, heel and coronary band The Ponies were also inoculated intradcrmally in the right commissure o the mouth Animals inoculated with each virus were housed in one room and allowed to mingle freely with an equal number of uninoculated contact animals of each species.<\/jats:p><jats:p>Clinical signs of infection, consisting of ulcers at the inoculation sites, were observed in the Chandipura study in two inoculated ponies, one inoculated steer and one inoculated goat. No elevated temperature was observed. Virus was isolated from the ulcerated tongue tissue but not from serial blood samples, oesophagcal-pharyngeal mucus samples, or from the tissues which were collected at necropsy. Precipitating antibody was not detected by the immunoelectro osmophoresis(IEOP) test in any of the pre- or post-serum samples except from two inoculated sheep at 29 days post-inoculation (D.P.I.). Low levels of neutralizing activity were dtedted in pre-inoculation serum from all steers, pigs, contact sheep, and one contact goa. By 15 D.P.I. all inoculated animals and contact ponies and steers exhibited increased neutralizing antibody titres.<\/jats:p><jats:p>In studies with the Isfahan virus, lesions developed only at the inoculation sites in the two ponies, and the virus was isolated. No virus was isolated from any blood, oesophageal-pharyngeal mucus samples or tisues collected at necropsy. All pre-inoculation sera were negative for neutralizing and precipitating antibodies. By 14 D.P.I. all inoculated animals exhibited neutralizing antibody, while all the contacts remained negative. The IEOP test remained negative for all animals throughout the experiment. A subpassage of a suspension of Isfahan-infected tongue tissue injected in to ponies and steers also yielded only firm swellings of lesser extent than the original reaction at the inoculation sites.<\/jats:p><jats:p>With both viruses, lethal infections were produced by intraacranial or intraperitoneal inoculation of day-old mice and hamsters, and by allantoic inoculation of embryonating chicken eggs. Adult mice, hamsters, guinea-pigs and rabbits produced serum antibodies but lacked clinical signs.<\/jats:p>","DOI":"10.1017\/s002217240006544x","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T12:49:38Z","timestamp":1255956578000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Susceptibility of various animals to the vesiculoviruses Isfahan and Chandipura"],"prefix":"10.1017","volume":"97","author":[{"given":"C. R.","family":"Wilks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,10,19]]},"reference":[{"key":"S002217240006544X_ref015","first-page":"179","article-title":"Development of an immunoelectroosmophoresis test for the detection and typing of antibodies to vesicular stomatitis viruses","volume":"48","author":"Wilks","year":"1984","journal-title":"Canadian Journal of Comparative Medicine"},{"key":"S002217240006544X_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF01309837"},{"key":"S002217240006544X_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400061039"},{"key":"S002217240006544X_ref011","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1977.26.299"},{"key":"S002217240006544X_ref009","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4049\/jimmunol.123.6.2518","article-title":"Antibody independent neutralization of vesicular stomatitis virus by human complement. 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Formation of VSV-liprotein complexes in human serum and complement-dependent virus lysis","volume":"123","author":"Mills","year":"1979","journal-title":"Journal of Immunology"},{"key":"S002217240006544X_ref006","first-page":"220","volume-title":"Statistical Method in Biological Assay","author":"Finney","year":"1978"},{"key":"S002217240006544X_ref005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0034-5288(18)34659-9","article-title":"Vesicular stomatitis virus \u2013 the relationship between some strains of the Indiana serotype","volume":"8","author":"Federer","year":"1967","journal-title":"Research in Veterinary Science"},{"key":"S002217240006544X_ref001","first-page":"208","volume-title":"Catalogue of Arthropod-borne Viruses of the World","year":"1967"},{"key":"S002217240006544X_ref002","first-page":"208","volume-title":"International Catalogue of Arboviruses Including Certain other Viruses of Vertebrates","author":"Berge","year":"1975"},{"key":"S002217240006544X_ref008","first-page":"276","volume-title":"Proceedings of the 87th Annual Meeting of the United States Animal Health Association","author":"House","year":"1983"},{"key":"S002217240006544X_ref007","first-page":"294","volume-title":"Diseases of Swine","author":"Hanson","year":"1981"},{"key":"S002217240006544X_ref010","first-page":"1306","article-title":"Experimental transmission of Chandipura virus by mosquitoes","volume":"55","author":"Rao","year":"1967","journal-title":"Indian Journal of Medical Research"},{"key":"S002217240006544X_ref003","first-page":"1295","article-title":"Chandipura: a new arbovirus isolated in India from patients with febrile illness","volume":"55","author":"Bhatt","year":"1967","journal-title":"Indian Journal of Medical Research"},{"key":"S002217240006544X_ref012","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-1-169"},{"key":"S002217240006544X_ref004","doi-asserted-by":"publisher","DOI":"10.1159\/000149062"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002217240006544X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T05:50:34Z","timestamp":1710654634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002217240006544X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,10]]}},"alternative-id":["S002217240006544X"],"URL":"https:\/\/doi.org\/10.1017\/s002217240006544x","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1986,10]]},"assertion":[{"value":"Cambridge University Press 1986","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}