{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T06:10:24Z","timestamp":1710655824211},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":8419,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This paper describes a microbiological study of 84 young adult men with clinical otitic infections. Gram-negative aerobic bacilli were frequently isolated from these patients diagnosed as having otitis externa or chronic suppurative otitis media, of which<jats:italic>Pseudomonas<\/jats:italic>species predominated.<\/jats:p><jats:p><jats:italic>Staphylococcus aureus, S. epidermidis<\/jats:italic>and aerobic<jats:italic>Corynebacterium<\/jats:italic>species (diphtheroids) were also found. About 40% of ear infections were attributed to otomycoses, chiefly from<jats:italic>Aspergillus<\/jats:italic>species and<jats:italic>Candida parapsilosis<\/jats:italic>. Antimicrobial susceptibility testing of the bacterial isolates revealed that<jats:italic>Pseudomonas<\/jats:italic>species were generally resistant to antibiotics commonly employed in general practice: ampicillin, erythromycin, co-trimoxazole, tetracycline and cephaloridine. However, polymjwin B, gentamicin and neomycin were active against some<jats:italic>Pseudomonas<\/jats:italic>isolates. Other Gram-negative bacilli were also mainly sensitiveto gentamicin, neomycin as well as co-trimoxazole. Disc diffusion and minimum inhibitor concentration studies demonstrated good activity of ceftazidime, cefoperazone, tobramycin and carbenicillin against strains of<jats:italic>Pseudomonas<\/jats:italic>species and other Gram-negative rods. Cefotaxime and cefoxitin were active against Gram-negative bacilli other than<jats:italic>Pseudomonas<\/jats:italic>species. Beta-lactamase production did not appear to be the main mechanism of resistance in these communityacquired Gram-negative bacillary isolates. The antimicrobial therapy of otological infections is reviewed.<\/jats:p>","DOI":"10.1017\/s0022172400065475","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T12:49:38Z","timestamp":1255956578000},"page":"385-392","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Bacterial and mycotic otological infections in Singapore"],"prefix":"10.1017","volume":"97","author":[{"given":"V. T. K.","family":"Chow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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