{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:07:11Z","timestamp":1764364031875},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T00:00:00Z","timestamp":1269475200000},"content-version":"unspecified","delay-in-days":9976,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A limited assessment of immunity to diphtheria revealed that only 44\u00b78 % of adults had protective levels (&gt; 0\u00b701 U\/ml) of diphtheria antitoxin in their sera. In the light of this information, it was decided to assess the suitability of Adult-type Tetanus-Diphtheria Vaccine as a replacement for Adsorbed Tetanus Vaccine in occupational health schemes. A comparative study of these vaccines showed that a single dose of each produced an equivalent rate and level of tetanus antitoxin responses. Adult-type Td Vaccine elicited more than fourfold increases of diphtheria antitoxin in 76 % of vaccinees. No statistically significant differences were observed in the clinical reactivity of the vaccines under test. However, the combined vaccine caused a slightly higher incidence of local reactions (pain, redness and swelling) while recipients of Adsorbed Tetanus Vaccine more frequently experienced pain.<\/jats:p>","DOI":"10.1017\/s0022172400071084","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T13:12:21Z","timestamp":1269522741000},"page":"513-519","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":18,"title":["A comparative clinical study of Adsorbed Tetanus Vaccine and Adult-type Tetanus\u2013Diphtheria Vaccine"],"prefix":"10.1017","volume":"89","author":[{"given":"S. P.","family":"Deacon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. T.","family":"Langford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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