{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:11:22Z","timestamp":1759990282477},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":7790,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The levels of prostaglandian E<jats:sub>2<\/jats:sub>(PGE<jats:sub>2<\/jats:sub>) were measured in aspirates of the effusion fluid from children suffering from secretory otitis media. The effects of naproxen 5 mg.\/kg. twice daily for eight weeks on the condition were studied in a placebocontrolled double-blind trial.<\/jats:p><jats:p>Nineteen middle-ear aspiraes from 13 children, six of whom had bilateral aspirations were examined. Detectable levels of PGE<jats:sub>2<\/jats:sub>and those without.<\/jats:p><jats:p>In a separate trial of naproxen, 11 patients received active drug and 13 received placebo. Naproxen had no significant effect on otalgia or hearing loss compared to placedo.<\/jats:p><jats:p>These findings suggest that is it unlikely that non-steroidal anti-inflammatory drug will be of therapeutic benefit in secretory otitis media.<\/jats:p>","DOI":"10.1017\/s0022215100099114","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:24:10Z","timestamp":1196418250000},"page":"263-266","source":"Crossref","is-referenced-by-count":13,"title":["Naproxen in otitis media with effusion"],"prefix":"10.1017","volume":"100","author":[{"given":"S.","family":"Abramovich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"O'Grady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"MacKinnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lavelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100099114_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100084334"},{"key":"S0022215100099114_ref007","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0090-6980(78)90122-3","article-title":"A radio-immunoassay for 6 Keto PGF1 F","volume":"15","author":"Salmon","year":"1978","journal-title":"Prostaglandins"},{"key":"S0022215100099114_ref004","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1542\/peds.43.5.833","article-title":"Effect of chronic otitis media on language and speech development","volume":"43","author":"Holm","year":"1969","journal-title":"Pediatrics"},{"key":"S0022215100099114_ref005","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S338"},{"key":"S0022215100099114_ref002","doi-asserted-by":"publisher","DOI":"10.3109\/05384916909070226"},{"key":"S0022215100099114_ref006","doi-asserted-by":"publisher","DOI":"10.3109\/03009747709095449"},{"key":"S0022215100099114_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1976.00780100043001"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100099114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T01:16:28Z","timestamp":1684113388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100099114\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["S0022215100099114"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100099114","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}