{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T01:50:25Z","timestamp":1695001825350},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":6875,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional treatments for non-allergic perennial rhinitis have proven somewhat unsuccessful in the control of rhinorrhoea when it is the predominant symptom. Hence, a double-blind cross-over trial of Ipratropium, a parasympatholytic, and placebo were carried out over a 12-week period. There was a significant reduction in rhinorrhoea during active treatment, with the most noticable effect being in the moderate-to-severe rhinorrhoea group. No significant effect was noted on nasal obstruction or sneezing and no serious side-effects were seen. A carry-on effect was noted when active treatment was used initially. However, the group given active treatment following placebo had a better result overall. A strong placebo effect was also noted in both groups, in keeping with a trial of this order.<\/jats:p>","DOI":"10.1017\/s0022215100106498","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:21:50Z","timestamp":1196418110000},"page":"799-801","source":"Crossref","is-referenced-by-count":3,"title":["Ipratropium bromide in the treatment of the \u2018rhinorrhoea syndrome\u2019"],"prefix":"10.1017","volume":"102","author":[{"given":"T. P.","family":"O'Dwyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100106498_ref006","first-page":"332","volume-title":"Nasal allergy","author":"Mygind","year":"1978"},{"key":"S0022215100106498_ref007","first-page":"226","volume-title":"Allergic and vasomotor rhinitis","author":"Wentges","year":"1979"},{"key":"S0022215100106498_ref002","first-page":"35","article-title":"Nasal metacholine provocation and Ipratropium therapy of perennial rhinitis","volume":"360","author":"Borum","year":"1979","journal-title":"Acta Otolaryngologica"},{"key":"S0022215100106498_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1979.tb01773.x"},{"key":"S0022215100106498_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1983.tb01440.x"},{"key":"S0022215100106498_ref004","first-page":"49","article-title":"Innervation of human nasal glands","volume":"1","author":"Cauna","year":"1972","journal-title":"Journal of Neurology"},{"key":"S0022215100106498_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6401.1258-a"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100106498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T19:19:47Z","timestamp":1558379987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100106498\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["S0022215100106498"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100106498","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}