{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:03:22Z","timestamp":1760522602053},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":6602,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report two cases of massive invasive pituitary adenoma with the unusual presentation of nasal obstruction. In both cases the diagnosis was only made when the obstructing tissue was removed. Cases reported previously have usually presented with severe focal neurological signs or a long history of neurological symptoms. These two cases are unusual in having minimal neurological deficits despite the extension of tumour into the nasopharynx and the middle and posterior cranial fossae. These extensions were well illustrated by computerised tomography. This unusual presentation is discussed with reference to the literature.<\/jats:p>","DOI":"10.1017\/s0022215100109478","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:20:57Z","timestamp":1196418057000},"page":"605-609","source":"Crossref","is-referenced-by-count":12,"title":["Invasive pituitary adenoma presenting with nasal obstruction"],"prefix":"10.1017","volume":"103","author":[{"given":"J. A.","family":"Dent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Rickhuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100109478_ref008","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:4<695::AID-CNCR2820030413>3.0.CO;2-I"},{"key":"S0022215100109478_ref006","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18002610417"},{"key":"S0022215100109478_ref001","first-page":"368","article-title":"Malignant adenomas of the chromophobe cells of the pituitary body","volume":"29","author":"Bailey","year":"1940","journal-title":"Archives of Pathology"},{"key":"S0022215100109478_ref005","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1972.36.6.0781"},{"key":"S0022215100109478_ref013","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1965.22.3.0268"},{"key":"S0022215100109478_ref010","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-4-703"},{"key":"S0022215100109478_ref002","first-page":"63","article-title":"Pituitary adenomas\u2013a reappraisal of their pathology and treatment","volume":"20","author":"Blaylock","year":"1977","journal-title":"Neurochirurgia"},{"key":"S0022215100109478_ref012","first-page":"377","article-title":"Treatment of intracavernous extensions of pituitary adenomas","volume":"10","author":"Mackay","year":"1978","journal-title":"Surgical Neurology"},{"key":"S0022215100109478_ref021","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-197912000-00014"},{"key":"S0022215100109478_ref014","first-page":"195","article-title":"Cerebrospinal fluid rhinorrhoea as a presentation of pituitary adenoma","volume":"6","author":"Nutkiewicz","year":"1980","journal-title":"Neurosurgery"},{"key":"S0022215100109478_ref016","doi-asserted-by":"publisher","DOI":"10.1159\/000308871"},{"key":"S0022215100109478_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100090587"},{"key":"S0022215100109478_ref011","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1977.00500240030005"},{"key":"S0022215100109478_ref015","doi-asserted-by":"publisher","DOI":"10.1148\/86.3.532"},{"key":"S0022215100109478_ref020","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1945.2.2.0126"},{"key":"S0022215100109478_ref003","first-page":"1324","article-title":"Pituitary tumours","volume":"56","author":"Bouloux","year":"1988","journal-title":"Surgery"},{"key":"S0022215100109478_ref007","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/003591574003300717","article-title":"Extrasellar extension of pituitary adenomas","volume":"33","author":"Jefferson","year":"1940","journal-title":"Proceedings of the Royal Society of Medicine"},{"key":"S0022215100109478_ref009","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.20.95"},{"key":"S0022215100109478_ref017","doi-asserted-by":"publisher","DOI":"10.1177\/000348943804700122"},{"key":"S0022215100109478_ref018","first-page":"201","article-title":"Nasal tumours of pituitary origin (report of a case)","volume":"47","author":"Shea","year":"1941","journal-title":"Transactions of the American Laryngology, Rhinology, and Otology Society"},{"key":"S0022215100109478_ref019","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197611000-00016"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100109478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:57:45Z","timestamp":1588118265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100109478\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["S0022215100109478"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100109478","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}