{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T08:19:36Z","timestamp":1648801176998},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":6357,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subtotal pars flaccida perforation was effected in <jats:italic>vitro<\/jats:italic> in rat tympanic membranes. The drums were subsequently kept in tissue culture and after various intervals studied by means of light and scanning electron microscopy. No complete covering of the perforation was seen, though a marked thickening and hyperplasia of the outer, keratinizing, squamous epithelium (OE) was evident. The inner, tympanal epithelium (IE) appeared swollen, containing rounded structures in the cytoplasm especially close to the contact area with the OE. Ingrowth of OE onto the tympanal side of the drum was seen particularly in the areas where the IE was sparse and completely lacking. Complete covering of a drum perforation seems to be dependent on the formation of supporting granulation tissue, probably resulting from an inflammatory reaction in the healing area.<\/jats:p>","DOI":"10.1017\/s0022215100111958","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:20:23Z","timestamp":1196400023000},"page":"91-96","source":"Crossref","is-referenced-by-count":2,"title":["Pars flaccida perforation in tissue culture: morphological study"],"prefix":"10.1017","volume":"104","author":[{"given":"L.-E.","family":"Stenfors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. G.","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. \u00d6.","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100111958_ref008","first-page":"216","volume-title":"Pathology of the Ear","author":"Schuknecht","year":"1974"},{"key":"S0022215100111958_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1987.tb08503.x"},{"key":"S0022215100111958_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100084346"},{"key":"S0022215100111958_ref002","first-page":"1302","article-title":"The healing process of tympanic membrane perforations","volume":"75","author":"Clawson","year":"1971","journal-title":"Transactions of the American Academy of Ophthalmology and Otolaryngology"},{"key":"S0022215100111958_ref007","first-page":"287","article-title":"The healing pattern of drum membrane","author":"Reynen","year":"1971","journal-title":"Acta Otolaryngologica Supplement"},{"key":"S0022215100111958_ref010","doi-asserted-by":"publisher","DOI":"10.3109\/00016488009131725"},{"key":"S0022215100111958_ref009","doi-asserted-by":"publisher","DOI":"10.3109\/00016488009131734"},{"key":"S0022215100111958_ref005","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800530317"},{"key":"S0022215100111958_ref001","first-page":"295","article-title":"The tympanal epithelium in normal and pathological conditions","volume":"32","author":"Boedts","year":"1978","journal-title":"Acta Oto-rhino-laryngologica (Belgica)"},{"key":"S0022215100111958_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1985.tb01561.x"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100111958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T18:03:40Z","timestamp":1558202620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100111958\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2]]}},"alternative-id":["S0022215100111958"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100111958","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2]]}}}