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The hallmark of NF2 is the development, in the second and third decades, of bilateral acoustic neuromas. NF1 is characterized by the appearance of cafe-au-lait spots and neurofibromas in addition to iris hamartomas, or Lisch nodules, of the eye, during the first and second decades.<\/jats:p><jats:p>Ten families were personally studied. A total of 16 members were found to be affected with NF2. A protocol for evaluation and review of subjects and relatives of NF2 families is proposed. A team approach, coordinating the expertise of multiple specialties is recommended.<\/jats:p>","DOI":"10.1017\/s0022215100121991","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:17:34Z","timestamp":1196417854000},"page":"6-11","source":"Crossref","is-referenced-by-count":11,"title":["A clinical, genetic and audiological study of patients and families with bilateral acoustic neurofibromatosis"],"prefix":"10.1017","volume":"107","author":[{"given":"W. 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