{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T14:45:10Z","timestamp":1648651510080},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":5111,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p><jats:italic>Cordyceps ophioglossoides<\/jats:italic> is one of the Japanese old \u2019Kanpoh\u2018 drugs used for metrorrhagia as a decoction. We found that CO-N, a galactosaminoglycan from <jats:italic>Cordyceps ophioglossoides<\/jats:italic>, reacted with sera from patients with some collagen diseases. By using CO-N, we made a new serological activity index (CO\u2014N reac tion). In the present study, we investigated CO-N reaction on patients with Wegener's granulomatosis (WG). The aggregation titres of CO-N (CO-N numbers) displayed a possible correlation with their clinical activity. CO-N reaction might also serve an important role in supporting the diagnosis of active WG and in helping to assess the degree of disease activity. The purpose of this report is to introduce this new serological activity index for Wegener's granulomatosis.<\/jats:p>","DOI":"10.1017\/s0022215100123849","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:16:53Z","timestamp":1196399813000},"page":"607-610","source":"Crossref","is-referenced-by-count":5,"title":["Co-N reaction \u2013 a new serological activity index \u2013 on Wegener's granulomatosis"],"prefix":"10.1017","volume":"107","author":[{"given":"Makoto","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiaki","family":"Tsuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ohmori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kitahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuzo","family":"Inouye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald B.","family":"Healy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100123849_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270453"},{"key":"S0022215100123849_ref005","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.36.4505"},{"key":"S0022215100123849_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(84)85146-0"},{"key":"S0022215100123849_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)91097-1"},{"key":"S0022215100123849_ref001","first-page":"571","article-title":"A new immunological parameter E-082 \u2013 its application for rheumatoid arthritis","volume":"10","author":"Ikeda","year":"1989","journal-title":"Therapeutic Research"},{"key":"S0022215100123849_ref004","first-page":"1256","article-title":"Anti-tumour activity of protein-bound polysaccharide from Cordyceps ophioglossoidesin mice","volume":"77","author":"Ohmori","year":"1986","journal-title":"Japanese Journal of Cancer Research (Gann)"},{"key":"S0022215100123849_ref006","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.36.4512"},{"key":"S0022215100123849_ref003","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.106.6_446"},{"key":"S0022215100123849_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6215(84)85043-0"},{"key":"S0022215100123849_ref007","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.37.1019"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100123849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T18:40:28Z","timestamp":1557945628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100123849\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["S0022215100123849"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100123849","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}