{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:32:14Z","timestamp":1761647534346},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4442,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A case is reported of a HIV\u2013positive patient with severe von Willebrand's disease describing the bleeding complications during and after tonsillectomy. This patient underwent surgery for asymmetrical tonsillar hypertrophy. The tonsils were spontaneously haemorrhaging and there therefore was a suspicion of neoplasia. Despite close cooperation between the ENT Department and the Haemophilia Centre, involving per\u2013operative Factor VIII monitoring and replacement, the patient suffered both protracted primary and secondary haemorrhages. We report this as a cautionary tale as our previous experience with mild to moderate haemophilia has been uncomplicated, but on this occcasion there was massive haemorrhage. We feel that tonsillectomy should not be undertaken in a patient with a severe bleeding disorder without an absolute indicate.<\/jats:p>","DOI":"10.1017\/s0022215100130373","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:15:32Z","timestamp":1196399732000},"page":"437-439","source":"Crossref","is-referenced-by-count":12,"title":["Bleeding after tonsillectomy in severe von Willebrand's disease"],"prefix":"10.1017","volume":"109","author":[{"given":"G. H.","family":"Alusi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Pasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Stearns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100130373_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02654.x"},{"key":"S0022215100130373_ref004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308253090803"},{"key":"S0022215100130373_ref001","first-page":"1991","article-title":"Hemostatic effect of normal platelet transfusion in severe von Willebrand disease patients","volume":"77","author":"Castillo","year":"1991","journal-title":"Btood"},{"key":"S0022215100130373_ref003","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198601000-00002"},{"key":"S0022215100130373_ref002","unstructured":"Khair K. Spence K. Majumdar G. , Savidge G. F. (1994) Continuous infusion therapy of very high purity von Willebrand Factor concentrate (VWF\u2013VHP) in patients with severe (type III) von Willebrand's disease. XXI Internationat Conference, World Federation of Haemophilia, p 198."},{"key":"S0022215100130373_ref007","first-page":"206","article-title":"Adenotonsillectomy in patients with inherited bleeding disorders","volume":"18","author":"Prinsley","year":"1993","journal-title":"Ctinicat Ototaryngology"},{"key":"S0022215100130373_ref008","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994004"},{"key":"S0022215100130373_ref009","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199204000-00011"},{"key":"S0022215100130373_ref005","first-page":"3130","article-title":"Comparison of four virus-inactivated plasma concentrates for treatment of severe von Willebrand disease: a cross-over randomized trial","volume":"79","author":"Mannucci","year":"1992","journal-title":"Btood"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100130373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T18:45:41Z","timestamp":1557773141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100130373\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["S0022215100130373"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100130373","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}