{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:42:08Z","timestamp":1791373328035,"version":"4.3.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4411,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aetiology of Meni\u00e8re's disease (MD) remains obscure, but is likely to be multifactorial, one of the factors being a genetic predisposition. Forty-one families with more than one living member with MD were ascertained and affected and normal relations examined. Blood was collected and DNA extracted and stored. In these families the mode of inheritance is autosomal dominant, the penetrance of the mutation being about 60 per cent. Some of the family members exhibit a partial syndrome, vestibular symptoms predominating. Sporadic and familial cases exhibit the same clinical features. The striking finding is the phenomenon of anticipation, whereby with successive generations there is an earlier age of onset and a tendency to more severe manifestation. The inference, considering that the cells which regulate endolymph are of neuroectodermal origin, is that, like other neurodegenerative disorders which show anticipation, MD manifestation is likely to be related to trinucloetide expansion within a gene.<\/jats:p>","DOI":"10.1017\/s0022215100130567","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:15:14Z","timestamp":1196399714000},"page":"499-502","source":"Crossref","is-referenced-by-count":58,"title":["Anticipation in Meni\u00e8re's disease"],"prefix":"10.1017","volume":"109","author":[{"given":"Andrew W.","family":"Morrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100130567_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1978.00790020041009"},{"key":"S0022215100130567_ref007","first-page":"9","volume-title":"Immunobiology, Histophysiology and Tumour Immunology","author":"Morrison","year":"1987"},{"key":"S0022215100130567_ref006","first-page":"145","volume-title":"Management of Sensorineural Deafness","author":"Morrison","year":"1975"},{"key":"S0022215100130567_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/ng1194-213"},{"key":"S0022215100130567_ref002","first-page":"561","article-title":"Meni\u00e8re's syndrome","volume":"46","author":"Brown","year":"1941","journal-title":"Archives of Neurology and Psychiatry"},{"key":"S0022215100130567_ref001","first-page":"233","article-title":"A neurological, ophthalmological and audiological survey of a suburban Jamaican community","volume":"16","author":"Ashcroft","year":"1967","journal-title":"West Indian Medical Journal"},{"key":"S0022215100130567_ref011","first-page":"9","volume-title":"Meni\u00e8re's disease. A comprehensive appraisal","author":"Watanabe","year":"1983"},{"key":"S0022215100130567_ref010","first-page":"3","volume-title":"Otologic Medicine and Surgery","volume":"1","author":"Van de Water","year":"1988"},{"key":"S0022215100130567_ref004","first-page":"10","article-title":"Review Article: Anticipation in myotonic dystrophy: new light on an old problem","volume":"51","author":"Harper","year":"1992","journal-title":"American Journal of Human Genetics"},{"key":"S0022215100130567_ref005","first-page":"202","article-title":"Genetic factors in otosclerosis","volume":"41","author":"Morrison","year":"1967","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"S0022215100130567_ref003","doi-asserted-by":"publisher","DOI":"10.1177\/014107687907201008"},{"key":"S0022215100130567_ref008","first-page":"35","article-title":"On genetic and environmental factors in Meni\u00e8re's disease","volume":"15","author":"Morrison","year":"1994","journal-title":"American Journal of Otology"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100130567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T17:53:22Z","timestamp":1557770002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100130567\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["S0022215100130567"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100130567","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]}}}