{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T16:23:21Z","timestamp":1761841401119},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4289,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pigmentation is reported to affect cisplatin-induced ototoxicity in adult humans. The hearing loss is worse in people with brown irises, than in those with blue irises. We assessed the hypothesis that cisplatintreated children with dark irises suffer more deterioration in auditory thresholds than do those with less pigmentation. For the 19 children whose data met the requirements of this observational retrospective study, we found a weak correlation (Spearman's r = 0.50; p&gt;0.05) of high frequency hearing loss (at 4000 Hz) and pigmentation. Blue or hazel-eyed children averaged 2.9 dB worsening at 4000 Hz, in contrast to 14.2 dB worsening for brown or black-eyed children.<\/jats:p><jats:p>Pigmentation may account for some of the individual susceptibility to cisplatin ototoxicity. We suggest that iris colour be included in future reports of cisplatin-related hearing loss<\/jats:p>","DOI":"10.1017\/s002221510013169x","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:15:00Z","timestamp":1196399700000},"page":"926-929","source":"Crossref","is-referenced-by-count":11,"title":["Cisplatin in children: hearing loss correlates with iris and skin pigmentation"],"prefix":"10.1017","volume":"109","author":[{"given":"N. Wendell","family":"Todd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos S.","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra B.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S002221510013169X_ref008","first-page":"1619","volume-title":"Pediatric Dermatology","author":"Lane","year":"1988"},{"key":"S002221510013169X_ref007","first-page":"218","article-title":"Potentiation of the ototoxic effect of cisplatin by hyperbaric oxygen therapy","volume":"109","author":"Ford","year":"1993","journal-title":"Otolaryngology \u2013 Head and Neck Surgery"},{"key":"S002221510013169X_ref005","first-page":"19","article-title":"Eye colour and susceptibility to noiseinduced permanent threshold shift","volume":"19","author":"Carter","year":"1980","journal-title":"Audiology"},{"key":"S002221510013169X_ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950190415"},{"key":"S002221510013169X_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100091374"},{"key":"S002221510013169X_ref004","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-198007000-00003"},{"key":"S002221510013169X_ref011","first-page":"1","article-title":"Cisplatin-induced ototoxicity: effect of pigmentation and inhibitory agents","volume":"103","author":"Schweitzer","year":"1993","journal-title":"Laryngoscope"},{"key":"S002221510013169X_ref012","first-page":"26","article-title":"Ototoxicity of chemotherapeutic agents","volume":"26","author":"Schweitzer","year":"1993","journal-title":"Otolarvngologic Clinics of North America"},{"key":"S002221510013169X_ref009","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199007000-00008"},{"key":"S002221510013169X_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100114689"},{"key":"S002221510013169X_ref002","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900302"},{"key":"S002221510013169X_ref006","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880180081015"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221510013169X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T16:48:53Z","timestamp":1557766133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221510013169X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["S002221510013169X"],"URL":"https:\/\/doi.org\/10.1017\/s002221510013169x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}