{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:41:25Z","timestamp":1772804485449,"version":"3.50.1"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4166,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a rare case of relapsing polychondritis with an initial symptom of inner ear involvement. This 53-year-old Japanese man experienced a hearing difficulty, tinnitus in both ears, and dizziness of sudden onset, but lacked auricular chondritis at that time, which is the most frequent finding in relapsing polychondritis. Thus it was difficult to reach a correct diagnosis. Steroid therapy, with oral prednisolone 15 mg daily, was effective. Almost two months after we began the steroid therapy, the patient complained of losing interest in his work and reported a hallucination vision on the TV screen, so the dose of prednisolone was decreased to 10 mg. The hallucinations then disappeared, but the serum level of C-reactive protein increased highly. To reduce the dose of prednisolone, we tried low-dose oral methotrexate. However, we had to discontinue it when the patient experienced severe vomiting and diarrhoea. As adjuvant therapy, we then administered Sho-saiko-to, Chinese herbal medicines with few side effects. Symptoms and laboratory abnormalities then improved markedly.<\/jats:p>","DOI":"10.1017\/s002221510013302x","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:14:52Z","timestamp":1196417692000},"page":"154-157","source":"Crossref","is-referenced-by-count":7,"title":["Relapsing polychondritis presented as inner ear involvement"],"prefix":"10.1017","volume":"110","author":[{"given":"Yasuyuki","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S002221510013302X_ref017","doi-asserted-by":"publisher","DOI":"10.1126\/science.6623056"},{"key":"S002221510013302X_ref015","first-page":"111","article-title":"Efficacy of an herbal medicine \u201cSho-saiko-to\u201d on the improvement of impaired cytokine production of peripheral blood mononuclear cells in patients with chronic viral hepatitis","volume":"37","author":"Yamashiki","year":"1992","journal-title":"Journal of Clinical and Laboratory Immunology"},{"key":"S002221510013302X_ref007","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210101207"},{"key":"S002221510013302X_ref013","first-page":"33","article-title":"Long-term experience with low dose weekly methotrexate in rheumatoid arthritis","volume":"17","author":"Weinblatt","year":"1990","journal-title":"Journal of Rheumatology"},{"key":"S002221510013302X_ref002","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197108000-00004"},{"key":"S002221510013302X_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00001"},{"key":"S002221510013302X_ref011","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199408000-00004"},{"key":"S002221510013302X_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)81307-3"},{"key":"S002221510013302X_ref010","first-page":"172","article-title":"Low dose methotrexate therapy in rheumatoid arthritis","volume":"30","author":"Shinozawa","year":"1990","journal-title":"The Ryumachi"},{"key":"S002221510013302X_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640130085034"},{"key":"S002221510013302X_ref006","first-page":"93","article-title":"Polychondropathia","volume":"6","author":"Jaksch-Wartenhorst","year":"1923","journal-title":"Wien Archives flu Innere Medizin"},{"key":"S002221510013302X_ref005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197811302992202"},{"key":"S002221510013302X_ref004","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1288\/00005537-197906000-00009","article-title":"Relapsing polychondritis: report of 10 cases","volume":"89","author":"Damiani","year":"1979","journal-title":"Laryngoscope"},{"key":"S002221510013302X_ref009","first-page":"113","article-title":"Morphological and functional interrelationship of auricular cartilage matrices","volume":"138","author":"Poole","year":"1984","journal-title":"Journal of Anatomy"},{"key":"S002221510013302X_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1986.tb02243.x"},{"key":"S002221510013302X_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371591"},{"key":"S002221510013302X_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1991.tb01932.x"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221510013302X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T21:18:56Z","timestamp":1708377536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221510013302X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["S002221510013302X"],"URL":"https:\/\/doi.org\/10.1017\/s002221510013302x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}