{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:23:24Z","timestamp":1770272604735,"version":"3.49.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4106,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Active chronic suppurative otitis media poses a management problem when patients are being considered for surgical treatment. Topical antibiotics have demonstrated varying degrees of success in the management of discharging ears. The introduction of quinolones has revived interest in these topical agents. This double-blind study compares two antibiotics, namely ofloxacin and neomycin-polymyxin B, with similar <jats:italic>in vitro<\/jats:italic> sensitivities to Gram positive and Gram negative organisms. Fifty-two patients were selected randomly and the results show that ofloxacin eardrops have marginal benefits in symptomatic improvement (89 per cent versus 79 per cent, <jats:italic>p<\/jats:italic> = 0.27) and bacterial eradication (81 per cent versus 75 per cent, <jats:italic>p<\/jats:italic> = 0.81) in active chronic suppurative otitis media. Significantly fewer patients (seven per cent versus 29 per cent, <jats:italic>p<\/jats:italic> = 0.04) in the ofloxacin group had active disease at the end of the two-week treatment. We recommend the use of ofloxacin eardrops in managing active chronic suppurative otitis media since it has high clinical efficacy, contains no steroid component and has no demonstrated risk of ototoxicity.<\/jats:p>","DOI":"10.1017\/s0022215100133523","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:14:27Z","timestamp":1196399667000},"page":"309-314","source":"Crossref","is-referenced-by-count":42,"title":["A double-blind comparative study of ofloxacin otic drops versus neomycin-polymyxin B-hydrocortisone otic drops in the medical treatment of chronic suppurative otitis media"],"prefix":"10.1017","volume":"110","author":[{"given":"Michael C. F.","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John K. S.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Andrew van Hasselt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100133523_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100105444"},{"key":"S0022215100133523_ref012","first-page":"170","article-title":"In vitro activity of ototopical drops against middle ear pathogens","volume":"14","author":"Ikeda","year":"1993","journal-title":"American Journal of Otology"},{"key":"S0022215100133523_ref002","unstructured":"Baba S. (1990b) A double-blind clinical trial of ofloxacin otic solution for the treatment of chronic suppurative otitis media and its acute exacerbations. Proceedings 3rd International Symposium on New Quinolones, Vancouver,European Journal of Clinical Microbiology and Infectious Diseases, pp 60\u201361."},{"key":"S0022215100133523_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100114185"},{"key":"S0022215100133523_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.5.661"},{"key":"S0022215100133523_ref014","first-page":"91","article-title":"Gentamicin-hydrocortisone ear-drops in chronic infections","author":"Kilcoyne","year":"1973","journal-title":"The Practitioner"},{"key":"S0022215100133523_ref011","first-page":"655","volume-title":"Antibiotics in Laboratory Medicine","author":"Hooper","year":"1991"},{"key":"S0022215100133523_ref025","first-page":"670","article-title":"Ofloxacin eardrop treatment for active chronic suppurative otitis media. Prospective randomized study","volume":"15","author":"Yuen","year":"1994","journal-title":"American Journal of Otology"},{"key":"S0022215100133523_ref016","doi-asserted-by":"publisher","DOI":"10.1177\/00034894900990S612"},{"key":"S0022215100133523_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6398.1024"},{"key":"S0022215100133523_ref017","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5701.114"},{"key":"S0022215100133523_ref006","first-page":"342","article-title":"Bacteriological evaluation of ofloxacin otic solution","volume":"45","author":"Deguchi","year":"1992","journal-title":"Japanese Journal of Antibiotics (Japan)"},{"key":"S0022215100133523_ref021","first-page":"89","article-title":"Are glucocorticoids in ear drops ototoxic?","volume":"493","author":"Spandow","year":"1992","journal-title":"Ada Oto-Laryngologica"},{"key":"S0022215100133523_ref001","unstructured":"Baba S. (1990a) A clinical study of ofloxacin otic solution on suppurative otitis media and otitis externa in children. Proceedings 3rd International Symposium on New Quinolones, Vancouver,European Journal of Clinical Microbiology and Infectious Diseases, pp 59\u201360."},{"key":"S0022215100133523_ref019","unstructured":"Ohyama M. , Nobori T. , Shima T. (1990) Clinical efficacy of ofloxacin otic solution in paediatric patients with otitis media et externa. Proceedings 3rd International Symposium on New Quinolones, Vancouver,European Journal of Clinical Microbiology and Infectious Diseases, pp 58\u201359."},{"key":"S0022215100133523_ref013","first-page":"49","article-title":"Horschaden durch ototoxische ohrtropfen. Ergebnisse Einer Umfrage. [Risk of inner ear damage from ototoxic eardrops.]","volume":"26","author":"Kellerhals","year":"1978","journal-title":"HNO (Berlin)"},{"key":"S0022215100133523_ref018","first-page":"1028","article-title":"A study of the influence of ofloxacin on the cochlea after topical administration into the middle ear cavity","volume":"34","author":"Nobori","year":"1988","journal-title":"Otologica Fukuoka"},{"key":"S0022215100133523_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880080064014"},{"key":"S0022215100133523_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870050057006"},{"key":"S0022215100133523_ref023","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199142050-00008"},{"key":"S0022215100133523_ref009","doi-asserted-by":"publisher","DOI":"10.1177\/00034894810903S214"},{"key":"S0022215100133523_ref015","first-page":"786","article-title":"The topical use of gentamicin in otorrhoea","volume":"203","author":"Mendonca","year":"1969","journal-title":"The Practitioner"},{"key":"S0022215100133523_ref005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01963.x"},{"key":"S0022215100133523_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(84)80008-3"},{"key":"S0022215100133523_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510009068X"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100133523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T18:09:13Z","timestamp":1557684553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100133523\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["S0022215100133523"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100133523","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}