{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T04:29:58Z","timestamp":1648873798890},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":4106,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sequential bacterial samples were obtained from the tonsillar surface of 19 consecutive patients (12 females, seven males; mean age 16.1 years, range four to 24 years) suffering from infectious mononucleosis with membranous tonsillitis. The specimens were examined with respect to aerobes (culture on blood and chocolate agar plates) and proportions of bacteria coated with immunoglobulins (secretory IgA, IgG, IgM) by using an immunofluorescence assay. In the early stage of the membranous tonsillitis phase, attachment of secretory IgA (SIgA) and IgG to the bacteria was greatly suppressed, as compared with healthy controls. Coating with IgM was evident only late in the membranous tonsillitis phase but was contracted and still evident even after the clinical throat symptoms had abated. The findings suggest that the B-lymphotropic Epstein-Barr virus, causative agent of infectious mononucleosis, exerts a transient suppression of immunoglobulin-coating of bacteria harboured on the tonsillar surfaces, with consequent abundant bacterial attachment to the epithelial cells and massive bacterial colonization on the palatine tonsils.<\/jats:p>","DOI":"10.1017\/s0022215100133572","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:14:27Z","timestamp":1196399667000},"page":"339-342","source":"Crossref","is-referenced-by-count":8,"title":["Immunoglobulin-coated bacteria on the tonsillar surface during infectious mononucleosis"],"prefix":"10.1017","volume":"110","author":[{"given":"Lars-Eric","family":"Stenfors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simo","family":"R\u00e4is\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100133572_ref003","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.31.100177.002225"},{"key":"S0022215100133572_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/165-Supplement_1-S167"},{"key":"S0022215100133572_ref001","first-page":"882","article-title":"De la vaccination contre les etats typhoides parla voie buccale","author":"Besredka","year":"1919","journal-title":"Annales de I'lnstitut Pasteur"},{"key":"S0022215100133572_ref004","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/121.3.303"},{"key":"S0022215100133572_ref012","first-page":"1139","article-title":"Secretory IgA- and IgG- coated bacteria in the nasopharynx of children","author":"Stenfors","year":"1991","journal-title":"Acta Otolaryngologica"},{"key":"S0022215100133572_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(93)90020-4"},{"key":"S0022215100133572_ref014","doi-asserted-by":"publisher","DOI":"10.1084\/jem.121.1.101"},{"key":"S0022215100133572_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959075"},{"key":"S0022215100133572_ref008","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.35.100181.002401"},{"key":"S0022215100133572_ref015","doi-asserted-by":"publisher","DOI":"10.1126\/science.177.4050.697"},{"key":"S0022215100133572_ref005","first-page":"55","article-title":"The clinical manifestations of infectious mononucleosis. A report of two hundred cases","author":"Hoagland","year":"1960","journal-title":"American Journal of Medical Sciences"},{"key":"S0022215100133572_ref006","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000605"},{"key":"S0022215100133572_ref007","unstructured":"Laboratory outline for training course in principles and bacterial applications of fluorescent antibody techniques. (1978) U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, Atlanta, Georgia 3033, USA., pp 53\u201383."},{"key":"S0022215100133572_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(92)90138-F"},{"key":"S0022215100133572_ref010","first-page":"91","article-title":"The presence of heterophile antibodies in infectious mononucleosis","author":"Paul","year":"1932","journal-title":"American Journal of Medical Sciences"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100133572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T18:08:45Z","timestamp":1557684525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100133572\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["S0022215100133572"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100133572","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}