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Using a silver-staining method, the variations of AgNORs have been studied in patients with atypical inflammatory lesion (n = 5), malignant reticulosis (n = 5) and Wegener's granulomatosis (n = 6). Our results reveal that there was a statistically significant difference (<jats:italic>p<\/jats:italic>&lt;0.01), highly suggestive of a difference in AgNOR counts between the atypical inflammatory lesion and Wegener's granulomatosis, with the Wegener's granulomatosis specimens having the higher irregular AgNORs, but the difference between Wegener's granulomatosis and malignant reticulosis is probably not clinically important. It is concluded that AgNORs may be useful in differentiating Wegener's granulomatosis from an atypical inflammatory lesion, and the simplified counting technique is adequate for the purpose.<\/jats:p>","DOI":"10.1017\/s0022215100138733","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:13:16Z","timestamp":1196417596000},"page":"825-828","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic importance of the nucleolar organizer regions in Wegener's granulomatosis"],"prefix":"10.1017","volume":"111","author":[{"given":"Wen L.","family":"Yue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng Z.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi H.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100138733_ref010","first-page":"961","article-title":"Wegener's granulomatosis: immunomicroscopic and ultrastructural study of four cases","volume":"114","author":"Gephardt","year":"1990","journal-title":"Archives of Pathology, Laboratory and Medicine"},{"key":"S0022215100138733_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100092197"},{"key":"S0022215100138733_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/BF00331257"},{"key":"S0022215100138733_ref024","doi-asserted-by":"publisher","DOI":"10.1508\/cytologia.55.339"},{"key":"S0022215100138733_ref011","first-page":"191","article-title":"The nucleolar organizer regions","volume":"49","author":"Hernadez-Verdun","year":"1983","journal-title":"Biology of the Cell"},{"key":"S0022215100138733_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/92.4.401"},{"key":"S0022215100138733_ref014","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198009000-00005"},{"key":"S0022215100138733_ref002","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990140109"},{"key":"S0022215100138733_ref003","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.5.1741"},{"key":"S0022215100138733_ref021","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711550206"},{"key":"S0022215100138733_ref013","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000307"},{"key":"S0022215100138733_ref015","first-page":"160","article-title":"Reliability and stability of the thymidine labeling index of breast cancer","volume":"54","author":"Meyer","year":"1986","journal-title":"Laboratory Investigation"},{"key":"S0022215100138733_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899083"},{"key":"S0022215100138733_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/BF01676192"},{"key":"S0022215100138733_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(89)90066-X"},{"key":"S0022215100138733_ref019","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930101)71:1<199::AID-CNCR2820710131>3.0.CO;2-S"},{"key":"S0022215100138733_ref020","doi-asserted-by":"publisher","DOI":"10.1007\/BF00217159"},{"key":"S0022215100138733_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(89)90371-6"},{"key":"S0022215100138733_ref023","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.43.2.157"},{"key":"S0022215100138733_ref025","first-page":"501","article-title":"Rapidly progressic crescentic glomerulonephritis associated with ANCA","volume":"144","author":"White","year":"1992","journal-title":"Journal of Lake States Medical Society"},{"key":"S0022215100138733_ref006","first-page":"141","article-title":"Nucleolar organizer regions in seminoma and intralobular malignant germ cells","volume":"3","author":"Delahunt","year":"1990","journal-title":"Modern Pathology"},{"key":"S0022215100138733_ref012","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199201000-00007"},{"key":"S0022215100138733_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.8.885"},{"key":"S0022215100138733_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1992.01880040038007"},{"key":"S0022215100138733_ref004","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711510203"}],"container-title":["The Journal of Laryngology &amp; 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