{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:35:44Z","timestamp":1760888144457},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":3527,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome, Osier's disease) is an inherited abnormality of the vasculature characterized by abnormal subepithelial vessels. Treatment has included repeated intranasal cautery, intra-arterial embolization and arterial ligation.<\/jats:p><jats:p>Treatment has included repeated intranasal cautery, intra-arterial embolization and arterial ligation. Historically, the operation of septodermoplasty and the use of systemic\/topical oestrogens have been the most effective and lasting treatments, but over time the telangiectasias recur. There is increasing interest in the use of a variety of lasers for intranasal photocoagulation.<\/jats:p><jats:p>A report of nine patients suffering from hereditary haemorrhagic telangiectasia who have undergone laser treatment with the Chromos pulsed dye laser is presented. This laser produces light energy at a wavelength of 585 nm and causes localized thermal damage to the blood vessel wall.<\/jats:p><jats:p>Initially, no patient saw an improvement in their symptoms, but following an average of approximately three courses of treatment, all have reported a measurable reduction in the number of epistaxes suffered.<\/jats:p><jats:p>Although no treatment completely resolves the epistaxis associated with this condition, we have found the pulsed dye laser to be effective at treating telangiectasias within the anterior nasal cavity.<\/jats:p>","DOI":"10.1017\/s0022215100139283","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:13:16Z","timestamp":1196417596000},"page":"1038-1041","source":"Crossref","is-referenced-by-count":22,"title":["Treatment of hereditary haemorrhagic telangiectasia by the pulsed dye laser"],"prefix":"10.1017","volume":"111","author":[{"given":"P. G.","family":"Harries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Brockbank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G.","family":"Shakespeare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A. S.","family":"Carruth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100139283_ref001","first-page":"362","article-title":"Hereditary epistaxis (Letter)","volume":"2","author":"Babington","year":"1865","journal-title":"Lancet"},{"key":"S0022215100139283_ref007","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198203000-00017"},{"key":"S0022215100139283_ref008","first-page":"19","article-title":"Hereditary hemorrhagic telangiectasia treated by laser surgery","volume":"26","author":"Illum","year":"1988","journal-title":"Rhinology"},{"key":"S0022215100139283_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1994.tb03198.x"},{"key":"S0022215100139283_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100052191"},{"key":"S0022215100139283_ref013","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110500507"},{"key":"S0022215100139283_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(78)90069-3"},{"key":"S0022215100139283_ref004","first-page":"63","article-title":"Multiple hereditary telangiectasias causing hemorrhage (hereditary hemorrhagic telangiectasia)","volume":"20","author":"Hanes","year":"1909","journal-title":"Bulletin of the Johns Hopkins Hospital"},{"key":"S0022215100139283_ref005","first-page":"135","article-title":"Hereditary hemorrhagic telangiectasia: Unsuccessful treatment with the flashamp-pulsed dye laser","volume":"30","author":"Haye","year":"1992","journal-title":"Rhinology"},{"key":"S0022215100139283_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780280027001"},{"key":"S0022215100139283_ref011","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7326\/0003-4819-53-1-147","article-title":"Permanent control of nosebleeds in patients with hereditary hemorrhagic telangiectasia","volume":"53","author":"Saunders","year":"1960","journal-title":"Annals of Internal Medicine"},{"key":"S0022215100139283_ref012","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1288\/00005537-198412000-00003","article-title":"Treatment of hereditary hemorrhagic telangiectasia by Nd-YAG laser photocoagulation","volume":"94","author":"Shapsay","year":"1984","journal-title":"Laryngoscope"},{"key":"S0022215100139283_ref014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902163200702"},{"key":"S0022215100139283_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90162-8"},{"key":"S0022215100139283_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12696885"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100139283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T21:17:55Z","timestamp":1708377475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100139283\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["S0022215100139283"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100139283","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}