{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:17:44Z","timestamp":1759058264233},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":3162,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1998,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A malignant course of juvenile laryngeal papillomatosis has rarely been reported. In the present case the patient had had laryngeal papillomas since the age of three years. The papillomas gradually spread to the entire respiratory system, and during 30 years the patient was operated on more than 80 times. At present an invasive tumour spreading from the tongue into the parapharyngeal space, extending to the cranial base, has been demonstrated by magnetic resonance imaging (MRI).<\/jats:p><jats:p>Intralesional therapy with Cidofovir, a promising antiviral drug against human papillomavirus (HPV) infection, was started with some clinical effect, although only on the superficial tumour growth. Histology of removed tumour tissue has demonstrated a mixture of exophytic and inverted growth pattern, and has mainly been interpreted as benign, in spite of a focally high mitotic index and an intermittent lack of maturation in the epithelium. In the most recent biopsies a verrucous carcinoma has been diagnosed. Expression of p53 was noted to increase in papillomas with time. All samples have been shown to harbour HPV 11, but no other HPV types.<\/jats:p>","DOI":"10.1017\/s0022215100142586","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:12:37Z","timestamp":1196399557000},"page":"1101-1104","source":"Crossref","is-referenced-by-count":17,"title":["An aggresive and invasive growth of juvenile papillomas involving the total respiratory tract"],"prefix":"10.1017","volume":"112","author":[{"given":"Bodil Laub","family":"Petersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gerstoft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poul","family":"Bretlau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Lindeberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100142586_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1996.tb01320.x"},{"key":"S0022215100142586_ref019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198305263082104"},{"key":"S0022215100142586_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954001"},{"key":"S0022215100142586_ref016","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197904000-00003"},{"key":"S0022215100142586_ref015","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100506"},{"key":"S0022215100142586_ref013","doi-asserted-by":"publisher","DOI":"10.3109\/00016488909127491"},{"key":"S0022215100142586_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01965.x"},{"key":"S0022215100142586_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1990.tb00444.x"},{"key":"S0022215100142586_ref009","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1099\/0022-1317-76-4-1057","article-title":"The use of general primers GP5 and GP6 elongated at their 3\u2032 ends with adjacent highly conserved sequences improves human papilloma virus detection by PCR","volume":"76","author":"Busman","year":"1995","journal-title":"Journal of General Virology"},{"key":"S0022215100142586_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(91)90045-H"},{"key":"S0022215100142586_ref005","doi-asserted-by":"publisher","DOI":"10.1177\/000348948008900602"},{"key":"S0022215100142586_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(93)90270-Q"},{"key":"S0022215100142586_ref001","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198706000-00005"},{"key":"S0022215100142586_ref021","first-page":"88","volume-title":"Laryngotracheal Problems in the Pediatric Patient","author":"Strong","year":"1979"},{"key":"S0022215100142586_ref007","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199109000-00010"},{"key":"S0022215100142586_ref012","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1997.00005.x"},{"key":"S0022215100142586_ref002","first-page":"2185","article-title":"Presence of human papilloma virus type 16 related sequences in verrucous carcinoma of the larynx","volume":"46","author":"Brandsma","year":"1986","journal-title":"Cancer Research"},{"key":"S0022215100142586_ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510053331418"},{"key":"S0022215100142586_ref008","unstructured":"H\u00f8rding U. 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