{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:38:09Z","timestamp":1761237489594},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":3042,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aetiology of M\u00e9ni\u00e8re's disease still remains unknown and its therapy is therefore empirical. As a result of immunological abnormalities demonstrated, steroids are commonly used in M\u00e9ni\u00e8re's disease. The place of topical steroids is still controversial. In this investigation topical dexamethasone is applied for three months through a ventilation tube in patients with intractable vertigo. The results showed that this treatment controls vertigo in 72 per cent of cases. No patient was worse than before treatment. Only in 17 per cent of the patients was there an increase in hearing level. When compared to the reports which used only tympanostomy tubes, this procedure seems to have a placebo effect with minimal harmful effects. It appears that transtympanic dexamethasone application is a good alternative to vestibular nerve section. Topical treatment may be sufficient in most patients. Systemic treatment may be used in patients where topical treatment fails.<\/jats:p>","DOI":"10.1017\/s0022215100143610","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:12:12Z","timestamp":1196417532000},"page":"217-221","source":"Crossref","is-referenced-by-count":26,"title":["Transtympanic dexamethasone application in M\u00e9ni\u00e8re's disease: an alternative treatment for intractable vertigo"],"prefix":"10.1017","volume":"113","author":[{"given":"Levent","family":"Sennaro\u011flu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzin","family":"Mottaghian Dini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonca","family":"Sennaro\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Gursel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soner","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100143610_ref002","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600303"},{"key":"S0022215100143610_ref012","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0030-6665(20)30398-4","article-title":"Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for M\u00e9ni\u00e8re's disease","volume":"29","author":"Shea","year":"1996","journal-title":"Otolaryngologic Clinics of North America"},{"key":"S0022215100143610_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"S0022215100143610_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/BF00874091"},{"key":"S0022215100143610_ref007","doi-asserted-by":"publisher","DOI":"10.1159\/000276016"},{"key":"S0022215100143610_ref008","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/014556139607500809","article-title":"The use of systemic steroids in otolaryngology","volume":"75","author":"Nadel","year":"1996","journal-title":"Ear, Nose and Throat Journal"},{"key":"S0022215100143610_ref003","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199412000-00012"},{"key":"S0022215100143610_ref006","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009122559"},{"key":"S0022215100143610_ref004","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109131486"},{"key":"S0022215100143610_ref011","first-page":"224","article-title":"Classification of M\u00e9ni\u00e8re's disease","volume":"4","author":"Shea","year":"1993","journal-title":"American Journal of Otology"},{"key":"S0022215100143610_ref010","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199110000-00009"},{"key":"S0022215100143610_ref009","first-page":"83","article-title":"Committee on hearing and equilibrium guidelines for reporting treatment results in M\u00e9ni\u00e8re's disease","volume":"96","author":"Pearson","year":"1985","journal-title":"Otolaryngology \u2013 Head and Neck Surgery"},{"key":"S0022215100143610_ref013","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/014556139607500806","article-title":"Intratympanic steroid treatment of inner ear disease and tinnitus (Preliminary report)","volume":"75","author":"Silverstein","year":"1996","journal-title":"Ear, Nose and Throat Journal"},{"key":"S0022215100143610_ref014","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210700109"},{"key":"S0022215100143610_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100066366"},{"key":"S0022215100143610_ref016","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00013"},{"key":"S0022215100143610_ref017","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S503"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100143610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T12:56:10Z","timestamp":1630241770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100143610\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S0022215100143610"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100143610","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,3]]}}}