{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:25:09Z","timestamp":1772814309376,"version":"3.50.1"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T00:00:00Z","timestamp":1183075200000},"content-version":"unspecified","delay-in-days":2889,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to investigate whether patients with chronic posterior laryngitis and symptoms of gastro-pharyngeal reflux benefit from a six-week therapy with pantoprozole. Twenty-nine out-patients with voice disorders (case history of at least two months) and simultaneous symptoms of gastropharyngeal reflux were recruited for this study. At the entry to the study a symptom questionnaire and a videolaryngo\/stroboscopy were completed. The symptom questionnaire and the video-laryngo\/stroboscopy were repeated after the six weeks of therapy with pantoprazole 40 mg once a day and again six weeks and three months after this follow-up, during which time the patient was without therapy.<\/jats:p><jats:p>Hoarseness, globus pharyngeus, sore throat, heartburn, and coughing were the symptoms which showed a significant (<jats:italic>p<\/jats:italic>&lt;0.05) recovery at the follow-ups (mean of hoarseness index: 7.28 to 0.92; mean of globus pharyngeus index: 3.14 to 0.58; mean of heartburn index: 2.86 to 0.5; mean of cough index: 1.72 to 0.25; mean of throat soreness index: 1.72 to 0.15). Laryngoscopy scores of the posterior laryngeal region, the glottic and the supraglottic region showed statistically significant improvement (<jats:italic>p<\/jats:italic>&lt;0.05) after the treatment with pantoprazole. The therapeutic effect exceeded the drug administration until the last follow-up (after three months). The medication was tolerated without side-effects in all patients.<\/jats:p><jats:p>A primary (ex juvantibus) therapy with proton pump inhibitors seems to be a therapeutic option for patients with long-lasting chronic inflammation of the larynx not responding to common therapy. In this case a six-week course of treatment has been shown to be sufficient.<\/jats:p>","DOI":"10.1017\/s0022215100145050","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T10:11:52Z","timestamp":1196417512000},"page":"734-739","source":"Crossref","is-referenced-by-count":27,"title":["Ex juvantibus approach for chronic posterior laryngitis: results of short-term pantoprazole therapy"],"prefix":"10.1017","volume":"113","author":[{"given":"Walter","family":"Habermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Eherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Lindbichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johann","family":"Raith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S0022215100145050_ref006","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"S0022215100145050_ref013","first-page":"1503","article-title":"Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring","volume":"84","author":"Wiener","year":"1989","journal-title":"American Journal of Gastroenterology"},{"key":"S0022215100145050_ref002","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196811000-00007"},{"key":"S0022215100145050_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199711000-00012"},{"key":"S0022215100145050_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF02358600"},{"key":"S0022215100145050_ref003","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400709"},{"key":"S0022215100145050_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90646-0"},{"key":"S0022215100145050_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90061-2"},{"key":"S0022215100145050_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(05)80254-1"},{"key":"S0022215100145050_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536709"},{"key":"S0022215100145050_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70350-4"},{"key":"S0022215100145050_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(96)80033-6"},{"key":"S0022215100145050_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00333-1"},{"key":"S0022215100145050_ref014","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/000348948909800601","article-title":"Gastroesophageal reflux and posterior laryngitis","volume":"98","author":"Wilson","year":"1989","journal-title":"Annals of Otology, Rhinology and Laryngology"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215100145050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T20:43:26Z","timestamp":1557434606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215100145050\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["S0022215100145050"],"URL":"https:\/\/doi.org\/10.1017\/s0022215100145050","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}