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Otol."],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the first case in the world literature of deliberate ablation of vestibular function in unilateral Meniere's disease with aminoglycoside eardrops (Garasone).<\/jats:p><jats:p>These findings give conclusive proof that Garasone eardrops, and by implication, all topical aminoglycoside ear drops can be vestibulotoxic in the presence of a tympanic membrane defect. The lower concentration of gentamicin in Garasone, in comparison to the standard intratympanic preparations for chemical ablation of vestibular function, may also offer a reduction in the potential risk of cochleotoxocity.<\/jats:p>","DOI":"10.1017\/s002221510014558x","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T05:11:53Z","timestamp":1196399513000},"page":"916-918","source":"Crossref","is-referenced-by-count":4,"title":["Presumed reduction of vestibular function in unilateral Meni\u00e8re's disease with aminoglycoside eardrops"],"prefix":"10.1017","volume":"113","author":[{"given":"Andrew P.","family":"Bath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory M.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manohar L.","family":"Bance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"key":"S002221510014558X_ref001","first-page":"149","article-title":"Ten years of experience with intratympanically applied streptomycin (gentamicin) in the therapy of Morbus Meniere","volume":"221","author":"Beck","year":"1978","journal-title":"Archives of Otolaryngology"},{"key":"S002221510014558X_ref005","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000104"},{"key":"S002221510014558X_ref010","first-page":"383","article-title":"Vestibular and audiologic functions in gentamicin treated Meniere's disease","volume":"9","author":"Moller","year":"1988","journal-title":"American Journal of Otology"},{"key":"S002221510014558X_ref007","first-page":"52","article-title":"Deafness after treatment with ear drops containing neomycin, gramicidin and dexamethasone","volume":"48","author":"Lind","year":"1986","journal-title":"Otorhinolaryngology"},{"key":"S002221510014558X_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100108011"},{"key":"S002221510014558X_ref011","first-page":"278","article-title":"Intratympanic gentamicin instillation as treatment of unilateral Meniere's disease: update of an ongoing study","volume":"14","author":"Nedzelski","year":"1993","journal-title":"American Journal of Otology"},{"key":"S002221510014558X_ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199701000-00017"},{"key":"S002221510014558X_ref014","first-page":"1","article-title":"Ablation therapy in the management of Meniere's disease","volume":"132","author":"Schuknecht","year":"1957","journal-title":"Acta Otolaryngologica (Stockholm)"},{"key":"S002221510014558X_ref003","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198806001-00002"},{"key":"S002221510014558X_ref004","first-page":"53","article-title":"Ototoxicity from ototopical aminoglycosides","volume":"26","author":"Hui","year":"1997","journal-title":"Journal of Otolaryngology"},{"key":"S002221510014558X_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00463571"},{"key":"S002221510014558X_ref008","first-page":"444","article-title":"Topical gentamicin vestibular toxicity","volume":"23","author":"Longridge","year":"1994","journal-title":"Journal of Otolaryngology"},{"key":"S002221510014558X_ref009","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00161.x"},{"key":"S002221510014558X_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199701000-00012"},{"key":"S002221510014558X_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100148157"},{"key":"S002221510014558X_ref016","first-page":"334","article-title":"Gentamicin persistence in rat endolymph and perilymph after two-day constant infusion","volume":"23","author":"Tran","year":"1983","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"S002221510014558X_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70284-5"},{"key":"S002221510014558X_ref018","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109131485"}],"container-title":["The Journal of Laryngology &amp; 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