{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:44:23Z","timestamp":1760982263173},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T00:00:00Z","timestamp":1184803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107000011_sec1\"><jats:title>Background:<\/jats:title><jats:p>Herbal remedies and other natural supplements have become popular alternative medical therapy. Patients using these products may present to ENT surgeons with epistaxis or with unexpected, excessive peri-operative bleeding.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000011_sec2\"><jats:title>Objective:<\/jats:title><jats:p>The purpose of this review was to consolidate the available data regarding herb\u2013drug interactions and the direct effects of herbal medicines and nutritional supplements in isolation, regarding disturbance in haemostasis, so as to emphasise their individual importance.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000011_sec3\"><jats:title>Method:<\/jats:title><jats:p>A literature review was performed using the Medline (PubMed) and UKMi databases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000011_sec4\"><jats:title>Results:<\/jats:title><jats:p>Searches of these databases revealed 24 herbal products with documented interactions with anticoagulants and 98 herbal products with theoretical interactions with the coagulation system. Herbal products with effects on coagulation when given alone were also documented.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000011_sec5\"><jats:title>Conclusion:<\/jats:title><jats:p>When encountering patients presenting with epistaxis, or in the elective surgical setting, a thorough enquiry about the use of herbal medicines is of great importance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107000011","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T14:08:58Z","timestamp":1184854138000},"page":"116-119","source":"Crossref","is-referenced-by-count":11,"title":["Potential effects of herbal medicines and nutritional supplements on coagulation in ENT practice"],"prefix":"10.1017","volume":"122","author":[{"given":"F","family":"Javed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Golagani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,19]]},"reference":[{"key":"S0022215107000011_ref6","first-page":"923","article-title":"Gingko biloba","volume":"68","author":"Seirpina","year":"2003","journal-title":"Am Fam Physician"},{"key":"S0022215107000011_ref4","unstructured":"4 UKMi. http:\/\/www.ukmi.nhs.uk\/Secure\/faqs\/archieve\/faq26.asp [July\u2013August 2006]"},{"key":"S0022215107000011_ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2001.00851.x"},{"key":"S0022215107000011_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200305000-00003"},{"key":"S0022215107000011_ref27","doi-asserted-by":"publisher","DOI":"10.1592\/phco.19.10.870.31558"},{"key":"S0022215107000011_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.06.1254"},{"key":"S0022215107000011_ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2002.02781.x"},{"key":"S0022215107000011_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000530.pub2"},{"key":"S0022215107000011_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(00)00195-1"},{"key":"S0022215107000011_ref7","first-page":"291","article-title":"Ginkgo biloba (EGb 761) in the treatment of equilibrium disorders","volume":"15","author":"Cesarani","year":"1998","journal-title":"Adv Ther"},{"key":"S0022215107000011_ref20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200110183451616"},{"key":"S0022215107000011_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(99)80031-2"},{"key":"S0022215107000011_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.2.208"},{"key":"S0022215107000011_ref17","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1365-2044.2005.04276.x","article-title":"Herbal medicines and post operative haemorrhage","volume":"60","author":"Jayasekera","year":"2005","journal-title":"Anesthesia"},{"key":"S0022215107000011_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-005-0114-4"},{"key":"S0022215107000011_ref16","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000078578.75597.F3"},{"key":"S0022215107000011_ref23","first-page":"82","article-title":"Epistaxis and oral anti-coagulant therapy","volume":"42","author":"Choudhury","year":"2004","journal-title":"Rhinology"},{"key":"S0022215107000011_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02850113"},{"key":"S0022215107000011_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01487.x"},{"key":"S0022215107000011_ref24","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Z442"},{"key":"S0022215107000011_ref25","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C503"},{"key":"S0022215107000011_ref26","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.5.509.34492"},{"key":"S0022215107000011_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199501000-00060"},{"key":"S0022215107000011_ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.134137000.x"},{"key":"S0022215107000011_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.18.1569"},{"key":"S0022215107000011_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534720"},{"key":"S0022215107000011_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1086-5802(16)31082-8"},{"key":"S0022215107000011_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200007000-00025"}],"container-title":["The Journal of Laryngology &amp; 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