{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:28:03Z","timestamp":1756384083974},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T00:00:00Z","timestamp":1184803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107000059_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the outcome and the change in quality of life of patients with chronic rhinitis after treatment with desloratadine.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000059_sec2\"><jats:title>Study design:<\/jats:title><jats:p>A prospective, open-label, non-blinded, non-randomised study of patients in a secondary and tertiary ENT referral centre.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000059_sec3\"><jats:title>Methods:<\/jats:title><jats:p>Chinese patients with chronic rhinitis were recruited. The patients were assessed by a questionnaire that included rhinitis symptoms score and SF-36 health survey components. Endoscopic assessment was performed with a rigid nasoendoscope and scored according to the modified endoscopic appearance score of Lund and Kennedy. A 12-week course of desloratadine 5\u00a0mg daily was prescribed. Patients were re-evaluated after treatment. A total of 47 subjects completed the study.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000059_sec4\"><jats:title>Results:<\/jats:title><jats:p>There were significant reductions in median rhinitis symptoms score, from six to five (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and in median endoscopic appearance score, from five to three (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Patients' general health perception was also improved after treatment (<jats:italic>p<\/jats:italic>\u00a0==\u00a00.022).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000059_sec5\"><jats:title>Conclusion:<\/jats:title><jats:p>Desloratadine may be an effective treatment which provides symptomatic relief and improves the quality of life in patients with chronic rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107000059","type":"journal-article","created":{"date-parts":[[2007,7,19]],"date-time":"2007-07-19T10:09:29Z","timestamp":1184839769000},"page":"1151-1155","source":"Crossref","is-referenced-by-count":9,"title":["Rhinitis symptoms and quality of life in patients with chronic perennial rhinitis treated with desloratadine"],"prefix":"10.1017","volume":"121","author":[{"given":"H C K","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C F","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A Van","family":"Hasselt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,19]]},"reference":[{"key":"S0022215107000059_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1995.tb00257.x"},{"key":"S0022215107000059_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550220048008"},{"key":"S0022215107000059_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62086-8"},{"key":"S0022215107000059_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90092-9"},{"key":"S0022215107000059_ref4","first-page":"193","article-title":"Quality of life in patients with seasonal allergic rhinitis is improved with desloratadine","volume":"5","author":"Corren","year":"2000","journal-title":"Allergy"},{"key":"S0022215107000059_ref6","volume-title":"SF36 Health Survey \u2013 Manual and Intrepretation Guide","author":"Ware","year":"1993"},{"key":"S0022215107000059_ref3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00102.x"},{"key":"S0022215107000059_ref13","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114239"},{"key":"S0022215107000059_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1995.tb01133.x"},{"key":"S0022215107000059_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00745.x"},{"key":"S0022215107000059_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510410s02"},{"key":"S0022215107000059_ref15","first-page":"460","article-title":"Population based norming of the Chinese (HK) version of the SF-36 health survey","volume":"21","author":"Lam","year":"1999","journal-title":"Hong Kong Practitioner"},{"key":"S0022215107000059_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb01154.x"},{"key":"S0022215107000059_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90359-X"},{"key":"S0022215107000059_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00105-X"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215107000059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T15:40:04Z","timestamp":1556725204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215107000059\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,19]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0022215107000059"],"URL":"https:\/\/doi.org\/10.1017\/s0022215107000059","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,19]]}}}