{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:56:15Z","timestamp":1649195775110},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221510700014X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>We present a rare case of an adult male with undiagnosed common variable immunodeficiency syndrome who presented to the ENT department with refractory chronic sinusitis and otitis media with effusion.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700014X_sec2\"><jats:title>Method:<\/jats:title><jats:p>Case report and a review of the international literature concerning common variable immunodeficiency syndrome in adults and upper respiratory tract involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700014X_sec3\"><jats:title>Results:<\/jats:title><jats:p>A 37-year-old male presented to the ENT department with refractory chronic sinusitis and otitis media with effusion. The diagnosis of common variable immunodeficiency syndrome was delayed, and difficult, primarily due to minimal symptoms with no lower respiratory tract involvement and negative past or family medical history.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700014X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Early diagnosis helps to prevent morbidity and even mortality. This article highlights how difficult and important it is to make an early diagnosis of common variable immunodeficiency syndrome. Early diagnosis will only be made by increased awareness of this condition.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221510700014x","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T08:30:52Z","timestamp":1185957052000},"page":"1204-1206","source":"Crossref","is-referenced-by-count":2,"title":["Common variable immunodeficiency syndrome: a difficult diagnostic problem"],"prefix":"10.1017","volume":"121","author":[{"given":"C","family":"Spyridakou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Phillipps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"S002221510700014X_ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00456.x"},{"key":"S002221510700014X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(92)90176-3"},{"key":"S002221510700014X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70003-2"},{"key":"S002221510700014X_ref7","volume-title":"Report on the audit of patients with primary antibody deficiency in the United Kingdom 1993\u20131996","author":"Spickett","year":"1998"},{"key":"S002221510700014X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90882-P"},{"key":"S002221510700014X_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6672.516"},{"key":"S002221510700014X_ref1","first-page":"173","article-title":"Primary immunodeficiency diseases","volume":"1","year":"1989","journal-title":"Immunodefic Rev"},{"key":"S002221510700014X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(86)90065-6"},{"key":"S002221510700014X_ref4","first-page":"31","article-title":"Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications","volume":"86","author":"Hermaszewski","year":"1993","journal-title":"Q J Med"},{"key":"S002221510700014X_ref10","first-page":"683","article-title":"Intravenous gammaglobulin for immunodeficiency: report from the European Group for Immunodeficiencies(EGID)","volume":"65","year":"1986","journal-title":"Clin Exp Immunol"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221510700014X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T19:40:06Z","timestamp":1556739606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221510700014X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,1]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S002221510700014X"],"URL":"https:\/\/doi.org\/10.1017\/s002221510700014x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,1]]}}}