{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:32:11Z","timestamp":1761647531955},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107000692_sec1\"><jats:title>Aims:<\/jats:title><jats:p>To investigate prognostic factors for survival and locoregional control in patients with stage I\u2013IVA hypopharyngeal cancer treated with laryngeal preservation radiotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000692_sec2\"><jats:title>Methods:<\/jats:title><jats:p>This study was a retrospective analysis of 108 patients with stage I\u2013IVA squamous cell carcinoma of the hypopharynx, treated with laryngeal preservation radiotherapy. Actuarial survival, disease-specific survival and local relapse-free survival were calculated, and multivariate analyses were performed using Cox's proportional hazards model.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000692_sec3\"><jats:title>Results:<\/jats:title><jats:p>After a median follow-up duration of 39 months, the five-year local relapse-free survival rate was 35 per cent for all patients, 66 per cent for those with stage I\u2013II disease, 46 per cent for those with stage III disease and 20 per cent for those with stage IVA disease (<jats:italic>p<\/jats:italic> = 0.004). Multivariate analyses showed that tumour and node stages were independent prognostic factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000692_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>Patients with stage I\u2013II disease were suitable for laryngeal preservation radiotherapy. For most patients with stage III\u2013IVA disease, other than those who were T<jats:sub>1<\/jats:sub> N<jats:sub>1<\/jats:sub> or T<jats:sub>2<\/jats:sub> N<jats:sub>1<\/jats:sub>, the treatment results were poor.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107000692","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T09:29:05Z","timestamp":1192181345000},"page":"506-512","source":"Crossref","is-referenced-by-count":11,"title":["Hypopharyngeal cancer treatment based on definitive radiotherapy: who is suitable for laryngeal preservation?"],"prefix":"10.1017","volume":"122","author":[{"given":"S-W","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-H","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-N","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-A","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A-C","family":"Shiau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F-J","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,10,12]]},"reference":[{"key":"S0022215107000692_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000237804.38761.81"},{"key":"S0022215107000692_ref3","doi-asserted-by":"publisher","DOI":"10.1258\/0022215021910302"},{"key":"S0022215107000692_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1995.tb01860.x"},{"key":"S0022215107000692_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.02.001"},{"key":"S0022215107000692_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(95)01539-S"},{"key":"S0022215107000692_ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.008"},{"key":"S0022215107000692_ref5","first-page":"1083","volume-title":"Uterine Cervix: Principles and Practice of Radiation Oncology","author":"Perez","year":"2004"},{"key":"S0022215107000692_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200205000-00011"},{"key":"S0022215107000692_ref1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/028418600750013465","article-title":"Hypopharyngeal squamous cell carcinoma. 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