{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:20:55Z","timestamp":1775305255454,"version":"3.50.1"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:00:00Z","timestamp":1192147200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107000874_sec1\"><jats:title>Objective:<\/jats:title><jats:p>The aim of this report was to highlight the fact that hearing loss in thalassaemia patients can be related to marrow expansion affecting the ossicles, resulting in a conductive loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000874_sec2\"><jats:title>Case report:<\/jats:title><jats:p>A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy. Otoxicity was assumed, but the deficit was later found to be of a conductive nature, due to marrow proliferation within the ossicular chain as a consequence of the disease process \u2013 a phenomenon previously unreported in the literature.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107000874_sec3\"><jats:title>Conclusion:<\/jats:title><jats:p>It is important to elucidate the precise nature of new onset hearing loss in patients receiving iron chelation therapy, in order to avoid unnecessary cessation of much needed medication, on the assumption of ototoxicity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107000874","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T05:34:10Z","timestamp":1192167250000},"page":"1253-1256","source":"Crossref","is-referenced-by-count":7,"title":["Marrow proliferation as a cause of hearing loss in beta-thalassaemia major"],"prefix":"10.1017","volume":"122","author":[{"given":"D","family":"Thio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Anslow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lennox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,10,12]]},"reference":[{"key":"S0022215107000874_ref2","first-page":"304","article-title":"Chelation therapy in \u03b2-thalassemia: the benefits and limitations of desferrioxamine","volume":"32","author":"Giardina","year":"1995","journal-title":"Semin Haematol"},{"key":"S0022215107000874_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(94)90008-6"},{"key":"S0022215107000874_ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000064748"},{"key":"S0022215107000874_ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198604033141402"},{"key":"S0022215107000874_ref5","first-page":"176","article-title":"Acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine","volume":"29","author":"Cases","year":"1988","journal-title":"Clin Nephrol"},{"key":"S0022215107000874_ref1","first-page":"313","volume-title":"Clinical Medicine","author":"Murphy","year":"1994"},{"key":"S0022215107000874_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90946-6"},{"key":"S0022215107000874_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100119383"},{"key":"S0022215107000874_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(95)01308-3"},{"key":"S0022215107000874_ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000207658"},{"key":"S0022215107000874_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.1.77"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215107000874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:06:23Z","timestamp":1556647583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215107000874\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,12]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0022215107000874"],"URL":"https:\/\/doi.org\/10.1017\/s0022215107000874","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,12]]}}}