{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T18:46:17Z","timestamp":1649011577809},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,7]],"date-time":"2008-01-07T00:00:00Z","timestamp":1199664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107001284_sec1\"><jats:title>Background:<\/jats:title><jats:p>Carbon monoxide is an endogenous vasodilator gas produced by the enzyme heme oxygenase (HO). HO is expressed in human nasal mucosa, but its pathophysiological role in nasal inflammatory diseases is not fully understood. The aim of this study was to detect and compare the expression of HO-1 and -2 isoforms in nasal polyps with normal nasal mucosa.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001284_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Immunohistochemical analysis using antibodies specific for HO-1 and -2 was conducted on nasal polyps from nine patients with allergic nasal polyposis, and on normal nasal mucosa from six controls.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001284_sec3\"><jats:title>Results:<\/jats:title><jats:p>Intense HO-1 immunoreactivity was observed in nasal polyp epithelium but was absent in normal nasal mucosa. HO-2 staining was observed in respiratory epithelium, vascular endothelium and seromucous glands, with no difference observed between nasal polyps and normal nasal mucosa.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001284_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>HO-1 expression is up-regulated in nasal polyp epithelium, supporting the theory that respiratory epithelium plays a role in the pathogenesis of nasal polyposis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107001284","type":"journal-article","created":{"date-parts":[[2008,2,11]],"date-time":"2008-02-11T09:38:07Z","timestamp":1202722687000},"page":"131-135","source":"Crossref","is-referenced-by-count":2,"title":["Immunolocalisation of heme oxygenase isoforms in human nasal polyps"],"prefix":"10.1017","volume":"123","author":[{"given":"S","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Di 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