{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:00:32Z","timestamp":1696320032193},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T00:00:00Z","timestamp":1203292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107001466_sec1\"><jats:title>Background:<\/jats:title><jats:p>Larsen's syndrome is primarily known as an orthopaedic disease. However, it has been found to be associated with conductive hearing loss caused by ossicular malformation. The possibility of a sensorineural hearing impairment as an additional part of this syndrome has been rather neglected in the past.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001466_sec2\"><jats:title>Method:<\/jats:title><jats:p>Case report and literature review.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001466_sec3\"><jats:title>Patient and results:<\/jats:title><jats:p>We present a teenage boy suffering from typical Larsen's syndrome. Despite no history of recurrent middle-ear infections, he showed a bilaterally symmetrical, mixed hearing loss dominated by an extensive sensorineural component. In order to review the corresponding literature, a Medline search was performed using the criteria \u2018Larsen's syndrome\u2019 and \u2018hearing loss\/deficit\u2019.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001466_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The literature review showed the presented case to be the first sufficiently documented report describing a predominant sensorineural hearing loss in a Larsen's syndrome patient. Although a specific association of Larsen's syndrome with sensorineural hearing loss is still speculative, this case might give grounds for further examinations of this rare finding.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107001466","type":"journal-article","created":{"date-parts":[[2008,2,18]],"date-time":"2008-02-18T11:28:27Z","timestamp":1203334107000},"source":"Crossref","is-referenced-by-count":4,"title":["Bilateral, mixed hearing loss with a predominant sensorineural component in Larsen's syndrome"],"prefix":"10.1017","volume":"122","author":[{"given":"I O","family":"Ott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R","family":"Issing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,2,18]]},"reference":[{"key":"S0022215107001466_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.13.6.538"},{"key":"S0022215107001466_ref7","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197254010-00007"},{"key":"S0022215107001466_ref5","first-page":"357","article-title":"Oral and craniofacial morphology of a patient with Larsen syndrome","volume":"6","author":"Tsang","year":"1986","journal-title":"J Craniofac Gen Dev Biol"},{"key":"S0022215107001466_ref3","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658040-00023"},{"key":"S0022215107001466_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb03468.x"},{"key":"S0022215107001466_ref18","first-page":"328","article-title":"Larsen's syndrome with mixed-type hearing loss","volume":"60","author":"Percin","year":"1994","journal-title":"Acta Orthop Belg"},{"key":"S0022215107001466_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(50)80268-8"},{"key":"S0022215107001466_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90080-U"},{"key":"S0022215107001466_ref15","first-page":"205","article-title":"Stapedotomy in Larsen's syndrome","volume":"11","author":"Horn","year":"1990","journal-title":"Am J Otol"},{"key":"S0022215107001466_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91562-6"},{"key":"S0022215107001466_ref10","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1542\/peds.71.6.942","article-title":"Cardiovascular manifestations in the Larsen syndrome","volume":"71","author":"Kiel","year":"1983","journal-title":"Pediatrics"},{"key":"S0022215107001466_ref2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677809005739"},{"key":"S0022215107001466_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80227-7"},{"key":"S0022215107001466_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(91)90073-O"},{"key":"S0022215107001466_ref12","first-page":"35","article-title":"Larsen's syndrome [in French]","volume":"39","author":"Renault","year":"1982","journal-title":"Arch Fr Pediatr"},{"key":"S0022215107001466_ref14","first-page":"45","article-title":"The association of a hearing deficit with Larsen's syndrome","volume":"10","author":"Herrmann","year":"1981","journal-title":"J Otolaryngol"},{"key":"S0022215107001466_ref6","first-page":"303","article-title":"Tracheomalacia in an infant with multiplex congenital (Larsen's) syndrome","volume":"90","author":"Grundfast","year":"1981","journal-title":"Ann Otol"},{"key":"S0022215107001466_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198705000-00024"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215107001466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T14:43:57Z","timestamp":1684248237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215107001466\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,18]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0022215107001466"],"URL":"https:\/\/doi.org\/10.1017\/s0022215107001466","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,18]]},"article-number":"e6"}}