{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:43:09Z","timestamp":1773445389879,"version":"3.50.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T00:00:00Z","timestamp":1203552000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107001545_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To compare the effect of remifentanil combined with desflurane or isoflurane on the quality of the operative field and surgical conditions, blood loss, and recovery during tympanoplasty or endoscopic sinus surgery.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001545_sec2\"><jats:title>Design:<\/jats:title><jats:p>Randomised, double-blinded clinical study.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001545_sec3\"><jats:title>Subjects:<\/jats:title><jats:p>Sixty-four patients were scheduled for elective tympanoplasty or endoscopic sinus surgery. The patients were randomly divided into two groups: desflurane or isoflurane. After anaesthesia induction, all patients received a continuous remifentanil infusion of 0.2\u20130.5 \u00b5g\/kg\/min until a mean arterial pressure of 65\u201375\u00a0mmHg was achieved. Heart rate and mean arterial pressure were recorded throughout anaesthesia. Blood loss was measured at the end of surgery. Achievement of a bloodless operative field was rated on a 100 mm visual analogue scale. Following completion of surgery, the time to extubation and to achievement of an Aldrete score of nine or more was recorded.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001545_sec4\"><jats:title>Results:<\/jats:title><jats:p>Sixty-three patients were evaluated. The total dose of remifentanil and the total blood loss were similar in both groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Time to extubation and to an Aldrete score of nine or more for the desflurane group was significantly less than for the isoflurane group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). No differences were found in the extent of achievement of a bloodless operative field, as assessed via visual analogue scale, comparing the study groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107001545_sec5\"><jats:title>Conclusion:<\/jats:title><jats:p>Although desflurane and isoflurane both enabled good surgical conditions (in terms of quality of operative field) and convenient induction of hypotension for tympanoplasty and endoscopic sinus surgery, the recovery characteristics of desflurane were better than those of isoflurane. Therefore, desflurane may be preferable to isoflurane in such circumstances.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107001545","type":"journal-article","created":{"date-parts":[[2008,2,21]],"date-time":"2008-02-21T10:29:13Z","timestamp":1203589753000},"page":"691-695","source":"Crossref","is-referenced-by-count":16,"title":["Hypotensive anaesthesia with remifentanil combined with desflurane or isoflurane in tympanoplasty or endoscopic sinus surgery: a randomised, controlled trial"],"prefix":"10.1017","volume":"122","author":[{"given":"K","family":"Kaygusuz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Ozdemir","family":"Kol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Mimaroglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,2,21]]},"reference":[{"key":"S0022215107001545_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(00)00145-8"},{"key":"S0022215107001545_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/47.7.745"},{"key":"S0022215107001545_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200308000-00019"},{"key":"S0022215107001545_ref13","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2003.470113.x"},{"key":"S0022215107001545_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(87)80366-0"},{"key":"S0022215107001545_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(99)90018-2"},{"key":"S0022215107001545_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF03015479"},{"key":"S0022215107001545_ref15","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198909000-00018"},{"key":"S0022215107001545_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1987.tb02549.x"},{"key":"S0022215107001545_ref9","first-page":"1995","article-title":"Comparison of propofol and sevoflurane anesthesia by means of blood loss during endoscopic sinus surgery","volume":"25","author":"Sivaci","year":"2004","journal-title":"Saudi Med J"},{"key":"S0022215107001545_ref8","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198606000-00021"},{"key":"S0022215107001545_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/BF00865405"},{"key":"S0022215107001545_ref18","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2000.440921.x"},{"key":"S0022215107001545_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael085"},{"key":"S0022215107001545_ref10","first-page":"852","article-title":"Application of controlled arterial hypotension in endoscopic rhinosurgery","volume":"39","author":"Cincikas","year":"2003","journal-title":"Medicina"},{"key":"S0022215107001545_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200411000-00012"},{"key":"S0022215107001545_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03019809"},{"key":"S0022215107001545_ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1213\/00000539-200007000-00023","article-title":"Recovery after anesthesia with remifentanil combined with propofol, desflurane, or sevoflurane for otorhinolaryngeal surgery","volume":"91","author":"Loop","year":"2000","journal-title":"Anesth Analg"},{"key":"S0022215107001545_ref17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1213\/00000539-199811000-00004","article-title":"Autoregulation of human inner ear blood flow during middle ear surgery with propofol or isoflurane anesthesia during controlled hypotension","volume":"87","author":"Preckel","year":"1998","journal-title":"Anesth Analg"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215107001545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T15:46:31Z","timestamp":1684251991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215107001545\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,21]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0022215107001545"],"URL":"https:\/\/doi.org\/10.1017\/s0022215107001545","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,21]]}}}