{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:31:34Z","timestamp":1761647494110},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T00:00:00Z","timestamp":1179100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221510700816X_sec1\"><jats:title>Introduction:<\/jats:title><jats:p>Oral ulceration has many causes and is a common presenting symptom in otolaryngology.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700816X_sec2\"><jats:title>Case report:<\/jats:title><jats:p>This article presents an unusual case of dual pathology oral ulceration in an elderly patient. Oral malignancy was initially suspected, but the history, examination and investigation showed that the oral ulceration was caused by actinomycosis infection and by nicorandil use.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700816X_sec3\"><jats:title>Discussion:<\/jats:title><jats:p>Cervicofacial acinomycosis is a rare, suppurative bacterial disease in which abscesses can form in the tissues and break through the skin, creating pus-discharging lesions. Nicorandil is a potassium channel blocker used in the treatment of ischaemic heart disease. It has been recently recognised as a cause of persistent ulcerative stomatitis.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510700816X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This case highlights the importance of a high index of suspicion for unusual and reversible causes of oral ulceration, and of dual pathology as a cause. Such vigilance enables early recognition and treatment of potentially reversible conditions.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221510700816x","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T10:14:06Z","timestamp":1179137646000},"page":"422-424","source":"Crossref","is-referenced-by-count":9,"title":["Dual pathology: cervicofacial actinomycosis and nicorandil-induced oral ulceration"],"prefix":"10.1017","volume":"122","author":[{"given":"H E V","family":"Cupples","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"McGahey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,5,14]]},"reference":[{"key":"S002221510700816X_ref7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.031831"},{"key":"S002221510700816X_ref3","first-page":"13","volume-title":"Medical Mycology","author":"Rippon","year":"1974"},{"key":"S002221510700816X_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199905)21:3<264::AID-HED12>3.0.CO;2-Y"},{"key":"S002221510700816X_ref6","first-page":"157","article-title":"Nicorandil-induced severe oral ulceration","volume":"50","author":"O'Sullivan","year":"2004","journal-title":"Journal of Irish Dental Association"},{"key":"S002221510700816X_ref2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1177\/014556139307200910","article-title":"Pediatric actinomycosis of the head and neck","volume":"72","author":"Stewart","year":"1993","journal-title":"Ear Nose and Throat Journal"},{"key":"S002221510700816X_ref5","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198409000-00013"},{"key":"S002221510700816X_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00172-3"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221510700816X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:32:33Z","timestamp":1587515553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221510700816X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,14]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S002221510700816X"],"URL":"https:\/\/doi.org\/10.1017\/s002221510700816x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,14]]}}}