{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:40:57Z","timestamp":1767339657325,"version":"3.33.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"unspecified","delay-in-days":3293,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107008626_sec1\"><jats:title>Objective:<\/jats:title><jats:p>One hundred and nine patients with primary antibody deficiencies were selected in order to determine the frequency of ENT complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107008626_sec2\"><jats:title>Method:<\/jats:title><jats:p>Demographic information and ENT medical histories were collected for each patient. Duration of study for each patient was divided into two periods of before diagnosis and after diagnosis and the initiation of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107008626_sec3\"><jats:title>Results:<\/jats:title><jats:p>Eighty-two of 109 patients (75.2 per cent) experienced ENT infections during the course of the disease (63: otitis media, 75: sinusitis and nine: mastoiditis). At the time of diagnosis, 52 (47.7 per cent) out of 109 patients presented with an ENT symptom. The frequencies of episodes were 27 for sinusitis and 25 for otitis media (one complicated with mastoiditis). After immunoglobulin replacement therapy the incidence of otitis media was reduced from 1.75 before treatment to 0.39 after treatment per patient per year (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). The incidence of sinusitis also significantly decreased from 2.38 to 0.78 (<jats:italic>p<\/jats:italic>value\u00a0=\u00a00.011).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107008626_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>ENT infections are common medical problems in primary antibody deficiency patients. Persistent and recurrent ENT infections should be suspected as originating from a possible underlying immunodeficiency.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107008626","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T10:28:42Z","timestamp":1180088922000},"page":"409-413","source":"Crossref","is-referenced-by-count":16,"title":["ENT manifestations in Iranian patients with primary antibody deficiencies"],"prefix":"10.1017","volume":"122","author":[{"given":"A","family":"Aghamohammadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Moazzami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Movahedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gharagozlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Abdollahzade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Pouladi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kouhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Moin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"doi-asserted-by":"publisher","key":"S0022215107008626_ref13","DOI":"10.1053\/hn.2003.v128.amhn0312811"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref4","DOI":"10.1159\/000095469"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref20","DOI":"10.1001\/archotol.1985.00800070042003"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref16","DOI":"10.1016\/S0194-5998(97)70001-9"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref9","DOI":"10.1006\/clim.2002.5241"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref8","DOI":"10.1136\/jcp.55.8.577"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref17","DOI":"10.1016\/j.jaci.2004.09.029"},{"key":"S0022215107008626_ref22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1542\/peds.87.3.311","article-title":"Immunologic defects in patients with refractory sinusitis","volume":"87","author":"Shapiro","year":"1991","journal-title":"Pediatrics"},{"key":"S0022215107008626_ref18","first-page":"8","article-title":"Chronic suppurative otitis media: a clinical overview","volume":"81","author":"Roland","year":"2002","journal-title":"Ear Nose Throat J"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref7","DOI":"10.1006\/clim.1999.4725"},{"key":"S0022215107008626_ref15","first-page":"1021","article-title":"Management of otitis media in a high risk population","volume":"27","author":"Morris","year":"1998","journal-title":"Aust Fam Physician"},{"key":"S0022215107008626_ref10","first-page":"108","article-title":"Ear, nose, and throat manifestations in patients with primary immunodeficiencies [in Spanish]","volume":"46","author":"Galicia","year":"1999","journal-title":"Rev Alerg Mex"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref2","DOI":"10.1023\/A:1020660416865"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref12","DOI":"10.1006\/clim.1999.4799"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref23","DOI":"10.1111\/j.1398-9995.2005.00756.x"},{"key":"S0022215107008626_ref14","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1517\/14656566.3.8.1073","article-title":"Otitis media","volume":"3","author":"Pichichero","year":"2002","journal-title":"Expert Opin Pharmacother"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref21","DOI":"10.1046\/j.1365-2273.2001.00456.x"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref1","DOI":"10.1016\/j.jaci.2005.12.1347"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref19","DOI":"10.1016\/j.ijporl.2006.04.013"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref11","DOI":"10.1136\/bmj.298.6672.516"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref5","DOI":"10.1067\/mai.2002.122466"},{"doi-asserted-by":"publisher","key":"S0022215107008626_ref3","DOI":"10.1016\/0092-8674(93)90667-F"},{"key":"S0022215107008626_ref6","first-page":"31","article-title":"Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications","volume":"86","author":"Hermaszewski","year":"1993","journal-title":"Q J Med"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215107008626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T17:35:31Z","timestamp":1737048931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215107008626\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0022215107008626"],"URL":"https:\/\/doi.org\/10.1017\/s0022215107008626","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"type":"print","value":"0022-2151"},{"type":"electronic","value":"1748-5460"}],"subject":[],"published":{"date-parts":[[2008,4]]}}}