{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:23:08Z","timestamp":1769037788752,"version":"3.49.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T00:00:00Z","timestamp":1183420800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215107009152_sec1\"><jats:title>Introduction:<\/jats:title><jats:p>The objectives of this preliminary, prospective, cohort study were to ascertain the characteristics of vestibular evoked myogenic potentials at threshold levels in two groups of M\u00e9ni\u00e8re's disease patients \u2013 acute and stable \u2013 and to identify whether vestibular evoked myogenic potentials can provide any specific, objective information to distinguish acute from stable M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107009152_sec2\"><jats:title>Subjects and methods:<\/jats:title><jats:p>The study was based at a tertiary neuro-otology centre. Twenty adult patients who fulfilled the American Academy of Otolaryngology\u2013Head and Neck Surgery<jats:sup>1<\/jats:sup> criteria for M\u00e9ni\u00e8re's disease were divided into two groups: 11 patients with acute M\u00e9ni\u00e8re's disease and nine patients with stable M\u00e9ni\u00e8re's disease. Eighteen healthy adult volunteers served as controls. All subjects underwent vestibular evoked myogenic potential testing with ipsilateral, short tone burst stimuli at 500\u00a0Hz, as well as pure tone audiometry. The patients also underwent caloric testing.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107009152_sec3\"><jats:title>Results:<\/jats:title><jats:p>Vestibular evoked myogenic potentials were present in all controls, and were present in 65 per cent of patients but absent in 35 per cent. The mean absolute threshold (<jats:sub>T<\/jats:sub>vestibular evoked myogenic potential)\u00a0\u00b1\u00a0standard deviation in normal controls was 116\u00a0\u00b1\u00a07.7 dBSPL; this did not differ statistically from that in patients, nor did it differ between acute and stable M\u00e9ni\u00e8re's disease. The p13\/n23 latencies at the threshold levels in the normal, acute and stable groups (mean\u00a0\u00b1\u00a0standard deviation) were respectively: 15\u00a0\u00b1\u00a02.2\u00a0ms\/23.0\u00a0\u00b1\u00a02.5\u00a0ms; 15.7\u00a0\u00b1\u00a00.9\u00a0ms\/23.7\u00a0\u00b1\u00a00.9\u00a0ms; and 15.3\u00a0\u00b1\u00a02.0\u00a0ms\/24.2\u00a0\u00b1\u00a01.9\u00a0ms. The mean interaural amplitude difference ratio (IAD)\u00a0\u00b1\u00a0standard deviation was significantly higher in the stable group compared with the acute group (0.54\u00a0\u00b1\u00a00.33 <jats:italic>vs<\/jats:italic> \u22120.15\u00a0\u00b1\u00a00.22; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and with the controls (0.54\u00a0\u00b1\u00a00.33 <jats:italic>vs<\/jats:italic> 0.1\u00a0\u00b1\u00a00.22; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215107009152_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>The parameter that best differentiated acute from stable M\u00e9ni\u00e8re's disease at threshold was the interaural amplitude difference ratio. Therefore, this parameter may be used to monitor the clinical course of M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215107009152","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T10:32:30Z","timestamp":1183458750000},"page":"452-457","source":"Crossref","is-referenced-by-count":13,"title":["Clinical value of tone burst vestibular evoked myogenic potentials at threshold in acute and stable M\u00e9ni\u00e8re's disease"],"prefix":"10.1017","volume":"122","author":[{"given":"V","family":"Osei-Lah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Ceranic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Luxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,7,3]]},"reference":[{"key":"S0022215107009152_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200103000-00025"},{"key":"S0022215107009152_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600418"},{"key":"S0022215107009152_ref26","first-page":"48","article-title":"Vestibular evoked myogenic potentials in multiple sclerosis: a comparison between onset and definite cases","volume":"11","author":"Alpini","year":"2005","journal-title":"Int Tinnitus J"},{"key":"S0022215107009152_ref16","doi-asserted-by":"publisher","DOI":"10.3109\/03005369209076644"},{"key":"S0022215107009152_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.8.815"},{"key":"S0022215107009152_ref30","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790320029008"},{"key":"S0022215107009152_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000027674"},{"key":"S0022215107009152_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb09202.x"},{"key":"S0022215107009152_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100145748"},{"key":"S0022215107009152_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00241975"},{"key":"S0022215107009152_ref1","first-page":"181","article-title":"American Academy of Otolaryngology\u2013Head and Neck and Surgery, Inc (AAOHNS)","volume":"113","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215107009152_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200405000-00022"},{"key":"S0022215107009152_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149452.83382.42"},{"key":"S0022215107009152_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199004000-00004"},{"key":"S0022215107009152_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00020"},{"key":"S0022215107009152_ref2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-10-06058.1994"},{"key":"S0022215107009152_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200111000-00014"},{"key":"S0022215107009152_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00020-8"},{"key":"S0022215107009152_ref28","doi-asserted-by":"publisher","DOI":"10.3109\/00016489209137000"},{"key":"S0022215107009152_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000216815.75512.03"},{"key":"S0022215107009152_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400911"},{"key":"S0022215107009152_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000176172.87141.5d"},{"key":"S0022215107009152_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200303000-00025"},{"key":"S0022215107009152_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00222-1"},{"key":"S0022215107009152_ref18","doi-asserted-by":"publisher","DOI":"10.3109\/03005369909090097"},{"key":"S0022215107009152_ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0002-x"},{"key":"S0022215107009152_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200209000-00018"},{"key":"S0022215107009152_ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.9.1069"},{"key":"S0022215107009152_ref21","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.6.660"},{"key":"S0022215107009152_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00256-9"},{"key":"S0022215107009152_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(96)00007-7"}],"container-title":["The Journal of Laryngology &amp; 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