{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:06:31Z","timestamp":1758823591518},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215108002582_sec1\"><jats:title>Objective:<\/jats:title><jats:p>We present a rare case of oesophageal perforation following ingestion of over-the-counter ibuprofen capsules.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002582_sec2\"><jats:title>Method:<\/jats:title><jats:p>Case report and literature review of pill oesophagitis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002582_sec3\"><jats:title>Case report:<\/jats:title><jats:p>A previously well, 18-year-old man presented with sudden onset, severe, retrosternal pain, dysphagia and odynophagia following ingestion of over-the-counter ibuprofen capsules. Plain X-ray films and a contrast-enhanced computed tomography scan indicated the diagnosis. The patient was successfully treated with non-operative management.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002582_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>To our knowledge, this is the first report in the world literature concerning oesophageal perforation with ibuprofen. We discuss pill-induced oesophageal injury and its prevention. Manufacturers, clinicians and patients can all take steps to avoid this potentially life-threatening complication.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215108002582","type":"journal-article","created":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T13:00:33Z","timestamp":1209646833000},"page":"864-866","source":"Crossref","is-referenced-by-count":14,"title":["Oesophageal perforation following ingestion of over-the-counter ibuprofen capsules"],"prefix":"10.1017","volume":"122","author":[{"given":"N P","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Rizk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"S0022215108002582_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.08.037"},{"key":"S0022215108002582_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536408"},{"key":"S0022215108002582_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02035023"},{"key":"S0022215108002582_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198609000-00013"},{"key":"S0022215108002582_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(89)90054-1"},{"key":"S0022215108002582_ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000128132"},{"key":"S0022215108002582_ref2","first-page":"1044","article-title":"A case of esophageal perforation due to a pill-induced ulcer successfully treated with conservative measures","volume":"91","author":"Yamaoka","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"S0022215108002582_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199904000-00002"},{"key":"S0022215108002582_ref15","first-page":"863","article-title":"Occult Boerhaave's syndrome without vomiting prior to presentation. 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