{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:44Z","timestamp":1773014444120,"version":"3.50.1"},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T00:00:00Z","timestamp":1211241600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215108002673_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To report a cluster of families affected by cholesteatoma in the East Anglia region of the UK.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002673_sec2\"><jats:title>Setting:<\/jats:title><jats:p>Otology service for the population of Norfolk and North Suffolk, East Anglia, UK.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002673_sec3\"><jats:title>Method:<\/jats:title><jats:p>Prospective and systematic collection of family history data for patients presenting with cholesteatoma over 10 years.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002673_sec4\"><jats:title>Result:<\/jats:title><jats:p>Several families were identified with affected individuals over several generations.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108002673_sec5\"><jats:title>Conclusion:<\/jats:title><jats:p>There is likely to be a genetic propensity for cholesteatoma in some individuals.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215108002673","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T09:30:20Z","timestamp":1211275820000},"page":"294-297","source":"Crossref","is-referenced-by-count":15,"title":["Familial cholesteatoma in East Anglia, UK"],"prefix":"10.1017","volume":"123","author":[{"given":"P","family":"Prinsley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,5,20]]},"reference":[{"key":"S0022215108002673_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/000348948609500408"},{"key":"S0022215108002673_ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00016480500475633"},{"key":"S0022215108002673_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00008"},{"key":"S0022215108002673_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106004117"},{"key":"S0022215108002673_ref1","first-page":"1066","article-title":"Middle ear cholesteatoma; present day concepts of eitiology and pathogenesis","volume":"38","author":"Lesinkas","year":"2002","journal-title":"Medicina (Kaunus)"},{"key":"S0022215108002673_ref5","first-page":"266","article-title":"Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications","volume":"9","author":"Albino","year":"1998","journal-title":"Am J Otol"},{"key":"S0022215108002673_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200011000-00023"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215108002673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T16:03:29Z","timestamp":1556640209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215108002673\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,20]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0022215108002673"],"URL":"https:\/\/doi.org\/10.1017\/s0022215108002673","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,20]]}}}