{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:18:42Z","timestamp":1771010322912,"version":"3.50.1"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,1]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>To assess the long term outcome of gentamicin inner-ear perfusion using the Silverstein MicroWick\u2122 in the treatment of M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec>Study design:<\/jats:title>Retrospective questionnaire survey of patients and review of medical records.<\/jats:p><\/jats:sec>Setting:<\/jats:title>A district general hospital.<\/jats:p><\/jats:sec>Participants:<\/jats:title>All 15 patients who completed a minimum follow up of at least 24 months were included.<\/jats:p><\/jats:sec>Main outcome measures:<\/jats:title>Subjective symptoms, change in hearing thresholds and Glasgow benefit inventory scores.<\/jats:p><\/jats:sec>Results:<\/jats:title>Based on the American Association of Otolaryngology-Head and Neck Surgery (1995) guidelines for reporting, 80 per cent of respondents obtained class A vertigo control and 20 per cent obtained class B control. Respondents' functional level improved from pre-operative levels of between three and six to post-operative levels of between one and three. Three respondents had pre-operative \u2018dead ears\u2019 and one developed the condition post-operatively. Hearing deteriorated further in three respondents, improved in two and remained unchanged in the rest. Respondents with class A control demonstrated improved quality of life, with a mean Glasgow benefit inventory total score of +34.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Transtympanic gentamicin therapy via the Silverstein MicroWick results in good vertigo control. Patients should however be made fully aware of the risk of hearing deterioration.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215108002776","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T14:16:49Z","timestamp":1212589009000},"page":"45-49","source":"Crossref","is-referenced-by-count":23,"title":["Transtympanic gentamicin treatment using Silverstein MicroWick in M\u00e9ni\u00e8re's disease patients: long term outcome"],"prefix":"10.1017","volume":"123","author":[{"given":"R","family":"Suryanarayanan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V R","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,6,4]]},"reference":[{"key":"S0022215108002776_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00023-3"},{"key":"S0022215108002776_ref3","doi-asserted-by":"publisher","DOI":"10.1258\/0022215041615083"},{"key":"S0022215108002776_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200111000-00033"},{"key":"S0022215108002776_ref4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/014556139907800816","article-title":"Use of a new device, the MicroWick, to deliver medication to the inner ear","volume":"78","author":"Silverstein","year":"1999","journal-title":"Ear Nose Throat J"},{"key":"S0022215108002776_ref2","doi-asserted-by":"publisher","DOI":"10.1258\/002221503321892299"},{"key":"S0022215108002776_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"S0022215108002776_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610500601"},{"key":"S0022215108002776_ref10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1177\/014556130608500811","article-title":"Long-term follow-up after gentamicin application via the Silverstein MicroWick in the treatment of Meniere's disease","volume":"85","author":"Hill","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"S0022215108002776_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(85)80013-2"},{"key":"S0022215108002776_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"S0022215108002776_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00008"},{"key":"S0022215108002776_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31802c7989"},{"key":"S0022215108002776_ref6","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/014556130108000709","article-title":"Use of the malleus handle as a landmark for localizing the round window membrane","volume":"80","author":"Silverstein","year":"2001","journal-title":"Ear Nose Throat J"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215108002776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T04:14:14Z","timestamp":1588738454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215108002776\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0022215108002776"],"URL":"https:\/\/doi.org\/10.1017\/s0022215108002776","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}