{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T05:28:21Z","timestamp":1697520501959},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T00:00:00Z","timestamp":1225152000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,4]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>To evaluate hearing results following intratympanic gentamicin perfusion in patients with M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec>Materials and methods:<\/jats:title>Middle-ear perfusion of 0.4\u00a0ml of gentamicin 40\u00a0mg\/ml solution was performed in M\u00e9ni\u00e8re's disease patients who had previously failed to respond to other medical treatment.<\/jats:p><\/jats:sec>Results:<\/jats:title>Between May 1999 and November 2005, 22 patients (mean age 58.5 years) underwent intratympanic gentamicin perfusion. Mean follow up was 30 months. At the first post-perfusion visit (four to six weeks following perfusion), three of the 22 patients (13.63 per cent) had a pure tone average improvement of at least 10\u00a0dB, 15 (68.18 per cent) showed no change and four (18.18 per cent) demonstrated a decrease in hearing of more than 10\u00a0dB. Regarding speech discrimination scores, one patient (4.54 per cent) exhibited an improvement of at least 15 per cent, 15 (68.18 per cent) showed no change and six (27.27 per cent) showed a decrease of at least 15 per cent. After long-term follow up (12\u201340 months following perfusion), 10 patients (45.45 per cent) showed stable hearing, and 12 (54.54 per cent) exhibited a pure tone average decrease of more than 10\u00a0dB. Six patients (27.27 per cent) showed a speech discrimination score decrease of at least 15 per cent, while 16 (72.72 per cent) had no change. Complete cessation of vertigo was reported by 20 of the 22 patients (90.9 per cent), while two (9.09 per cent) reported episodic vertigo spells.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Intratympanic gentamicin perfusion provides effective control of vertigo in patients with M\u00e9ni\u00e8re's disease. However, significant hearing loss may occur immediately after perfusion; therefore, this treatment should be considered only for patients whose hearing has already been affected by the disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215108003150","type":"journal-article","created":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T11:49:04Z","timestamp":1225194544000},"page":"379-382","source":"Crossref","is-referenced-by-count":6,"title":["Hearing results following intratympanic gentamicin perfusion for M\u00e9ni\u00e8re's disease"],"prefix":"10.1017","volume":"123","author":[{"given":"E","family":"Kyrodimos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Aidonis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sismanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,10,28]]},"reference":[{"key":"S0022215108003150_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00023-3"},{"key":"S0022215108003150_ref10","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v120.a91763"},{"key":"S0022215108003150_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"S0022215108003150_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00009"},{"key":"S0022215108003150_ref6","first-page":"209","article-title":"Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy","volume":"20","author":"Minor","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215108003150_ref5","first-page":"357","article-title":"Intratympanic gentamicin titration therapy for intractable Meniere's disease","volume":"20","author":"Atlas","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215108003150_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"S0022215108003150_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0988-0"},{"key":"S0022215108003150_ref3","first-page":"554","article-title":"Meta-analysis of intratympanic gentamicin","volume":"26","author":"Longridge","year":"2005","journal-title":"Otol Neurotol"},{"key":"S0022215108003150_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"S0022215108003150_ref11","first-page":"586","article-title":"Inner ear perfusion and the role of round window patency","volume":"18","author":"Silverstein","year":"1997","journal-title":"Am J Otol"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215108003150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T19:36:48Z","timestamp":1556653008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215108003150\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,28]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0022215108003150"],"URL":"https:\/\/doi.org\/10.1017\/s0022215108003150","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,28]]}}}