{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:45:39Z","timestamp":1780962339504,"version":"3.54.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T00:00:00Z","timestamp":1221609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215108003629_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To analyse correlations between quality of life measures, aspiration and extent of surgical resection in patients who have undergone free-flap tongue reconstruction.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108003629_sec2\"><jats:title>Patients and methods:<\/jats:title><jats:p>Nine consecutive patients (seven men and two women; average age 51 years) who had been diagnosed with T<jats:sub>4a<\/jats:sub> carcinoma of the mobile tongue and\/or tongue base and treated by glossectomy, free-flap reconstruction, and either radiation therapy or chemoradiation responded to the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire, the performance status scale questionnaire and the hospital anxiety\u2013depression scale questionnaire, an average of 43 months after treatment (range 18\u201383 months). Aspiration was evaluated by fibre-optic laryngoscopy. Correlations between quality of life domain scores, extent of surgery and the presence of aspiration were evaluated using non-parametric statistical analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108003629_sec3\"><jats:title>Results:<\/jats:title><jats:p>Scores for the swallowing and aspiration domains of the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire were significantly correlated with the extent of tongue base resection (Spearman's correlation, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037 and 0.042, respectively). Despite a strong correlation between the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire results and the performance status scale global scores (correlation coefficient\u00a0=\u00a00.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.048), the performance status scale domain scores were not correlated with the extent of tongue resection. Clinically apparent aspiration was not correlated with the extent of tongue resection, nor were the anxiety or depression scores. However, clinically apparent aspiration was significantly related to the swallowing and aspiration domain scores of the European Organization for Research and Treatment of Cancer Head and Neck-35 questionnaire (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.017 in both cases).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215108003629_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>Our results imply that the volume of tongue base resection is a major factor in swallowing- and aspiration-related quality of life following tongue resection and free-flap reconstruction. Free-flap reconstruction does not seem to palliate the effect of the loss of functional tongue base volume, as regards swallowing-related quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215108003629","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T04:31:18Z","timestamp":1221625878000},"page":"550-554","source":"Crossref","is-referenced-by-count":51,"title":["Quality of life after free-flap tongue reconstruction"],"prefix":"10.1017","volume":"123","author":[{"given":"D M","family":"Hartl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Dauchy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Escande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Bretagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Janot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kolb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,9,17]]},"reference":[{"key":"S0022215108003629_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199809020-00009"},{"key":"S0022215108003629_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199710000-00005"},{"key":"S0022215108003629_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00249-9"},{"key":"S0022215108003629_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880300007002"},{"key":"S0022215108003629_ref11","first-page":"19","volume-title":"UICC International Union Against Cancer. 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