{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:50:09Z","timestamp":1773683409041,"version":"3.50.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T00:00:00Z","timestamp":1232409600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215109004538_sec1\"><jats:title>Background:<\/jats:title><jats:p>Adenosquamous carcinoma is a very rare tumour which is characterised pathologically by the simultaneous presence of distinct areas of adenocarcinoma and squamous cell carcinoma. Generally, adenosquamous carcinoma has an aggressive clinical course and is associated with a poor prognosis. Most cases have been treated by surgery alone or combined with radiotherapy. Chemotherapy is rarely used in treating adenosquamous carcinoma, and it has been difficult to establish treatment guidelines due to the paucity of cases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004538_sec2\"><jats:title>Case:<\/jats:title><jats:p>We report a case of adenosquamous carcinoma which arose in the maxillary sinus of a 77-year-old man. Despite surgical treatment and chemoradiotherapy to the primary site, he developed bilateral neck metastases after the surgery. The patient was treated with S-1, a novel oral fluoropyrimidine anticancer agent, with a complete (albeit finite) response.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004538_sec3\"><jats:title>Conclusion:<\/jats:title><jats:p>This report presents the aggressive character of adenosquamous carcinoma and the possible role of S-1 in the treatment of this uncommon neoplasm.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215109004538","type":"journal-article","created":{"date-parts":[[2009,1,20]],"date-time":"2009-01-20T10:05:54Z","timestamp":1232445954000},"page":"1271-1275","source":"Crossref","is-referenced-by-count":5,"title":["Adenosquamous carcinoma of maxillary sinus: case showing complete response to S-1"],"prefix":"10.1017","volume":"123","author":[{"given":"S","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hanata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nanjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,1,20]]},"reference":[{"key":"S0022215109004538_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196811)22:6<1140::AID-CNCR2820220610>3.0.CO;2-1"},{"key":"S0022215109004538_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01881.x"},{"key":"S0022215109004538_ref2","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2002.123462"},{"key":"S0022215109004538_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80103-9"},{"key":"S0022215109004538_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-60592-5"},{"key":"S0022215109004538_ref15","volume-title":"Oral and Maxillofacial Pathology","author":"Neville","year":"2002"},{"key":"S0022215109004538_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90423-1"},{"key":"S0022215109004538_ref8","first-page":"173","article-title":"Adenosquamous carcinoma of the facial bones, skull base, and calvaria: CT and MR manifestations","volume":"18","author":"Som","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0022215109004538_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000083008"},{"key":"S0022215109004538_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90422-X"},{"key":"S0022215109004538_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00106-9"},{"key":"S0022215109004538_ref14","volume-title":"Atlas of Tumor Pathlogy","author":"Ellis","year":"1996"},{"key":"S0022215109004538_ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/81.6.696"},{"key":"S0022215109004538_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200402000-00001"},{"key":"S0022215109004538_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0616-9"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215109004538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T10:11:32Z","timestamp":1556619092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215109004538\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,20]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0022215109004538"],"URL":"https:\/\/doi.org\/10.1017\/s0022215109004538","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,20]]}}}