{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T12:12:57Z","timestamp":1744719177055},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"unspecified","delay-in-days":2868,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215109004836_sec1\"><jats:title>Introduction:<\/jats:title><jats:p>An unusual clivus mass is reported, following investigation of memory disturbance and headaches in a patient with \u03b2 thalassaemia and sickle cell disease. This lesion proved to be a site of extramedullary haematopoiesis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004836_sec2\"><jats:title>Radiological findings:<\/jats:title><jats:p>Computed tomography demonstrated a 2\u00a0cm mass at the base of the sphenoid. However, magnetic resonance imaging showed little bony expansion, and the differential diagnosis included chordoma, dermoid cyst and fibrodysplasia.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004836_sec3\"><jats:title>Histological findings:<\/jats:title><jats:p>Examination of the biopsy showed the presence of bone marrow demonstrating erythroid hyperplasia and small aggregates of B-cell lymphocytes. The features were considered compatible with erythroid hyperplasia associated with haemolytic anaemia.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004836_sec4\"><jats:title>Management:<\/jats:title><jats:p>The patient was reassured that she did not have a neoplastic lesion, and was referred back to the haematologists for further management of her sickling \u03b2 thalassaemia.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109004836_sec5\"><jats:title>Conclusions:<\/jats:title><jats:p>Extramedullary haematopoiesis occurs outside the reticuloendothelial system in response to haemolytic anaemia. Extramedullary haematopoiesis causing a clivus mass is an unusual ENT presentation. Such haematopoiesis is occasionally seen in the calvarial skull, but this is the first report of this process occurring in the anterior skull base, to our knowledge.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215109004836","type":"journal-article","created":{"date-parts":[[2009,3,2]],"date-time":"2009-03-02T11:25:52Z","timestamp":1235993152000},"source":"Crossref","is-referenced-by-count":3,"title":["Unusual clivus lesion demonstrating extramedullary haematopoiesis: case report"],"prefix":"10.1017","volume":"123","author":[{"given":"K","family":"Kulendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sandison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,3,8]]},"reference":[{"key":"S0022215109004836_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198408000-00042"},{"key":"S0022215109004836_ref10","first-page":"934","article-title":"Extramedullary haematopoiesis involving the bilateral lacrimal fossae","volume":"27","author":"Baskurt","year":"2006","journal-title":"Am J Neuroradiol"},{"key":"S0022215109004836_ref2","first-page":"809","article-title":"Extra-medullary hematopoiesis causing bilateral optic atrophy in beta thalassaemia\/Hb E disease","volume":"90","author":"Ittipunkul","year":"2007","journal-title":"J Med Assoc Thai"},{"key":"S0022215109004836_ref1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701793735"},{"key":"S0022215109004836_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/BF00361428"},{"key":"S0022215109004836_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100122"},{"key":"S0022215109004836_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199705000-00011"},{"key":"S0022215109004836_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200403000-00021"},{"key":"S0022215109004836_ref3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/000348940211100407","article-title":"Isolated sphenoid sinus disease: an analysis of 122 cases","volume":"111","author":"Wang","year":"2002","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"S0022215109004836_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050037"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215109004836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T19:00:51Z","timestamp":1556650851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215109004836\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022215109004836"],"URL":"https:\/\/doi.org\/10.1017\/s0022215109004836","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]},"article-number":"e15"}}