{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:18:45Z","timestamp":1773829125313,"version":"3.50.1"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"S31","license":[{"start":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T00:00:00Z","timestamp":1242950400000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215109005052_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>We had previously treated patients with advanced stage laryngeal cancer by laryngectomy with or without post-operative radiotherapy. In order to improve such patients' quality of life, we sought to preserve the larynx by selective (intra-arterial), rapid infusion chemotherapy combined with radiotherapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005052_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Chemotherapy was administered intra-arterially in the angiography suite via transfemoral catheterisation of the superior thyroid artery. Patients received up to four once-weekly infusions of cisplatin (75\u00a0mg\/patient) with simultaneous intravenous administration of sodium thiosulphate, a neutralising agent. Patients also received external radiation simultaneously at a dose of 1.8 or 2.0 Gy per fraction, once daily for five days a week for 7 weeks.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005052_sec3\"><jats:title>Results:<\/jats:title><jats:p>Intra-arterial infusion chemo-radiotherapy was performed in eight patients with advanced laryngeal carcinoma (four glottic, three supraglottic and one subglottic type carcinoma). A complete response was achieved at the primary site and at lymph node metastases in all eight patients. Overall toxic side effects were modest. No catheter-related thrombo-embolic complications were observed during any of the chemotherapy sessions.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005052_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>Selective (intra-arterial), rapid infusion chemo-radiotherapy may enable laryngeal preservation in patients with advanced laryngeal carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215109005052","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T10:14:31Z","timestamp":1242987271000},"page":"30-34","source":"Crossref","is-referenced-by-count":9,"title":["Selective (intra-arterial), rapid infusion chemo-radiotherapy to preserve the larynx in advanced laryngeal carcinoma: preliminary results"],"prefix":"10.1017","volume":"123","author":[{"given":"T","family":"Nakashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Mihoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Umeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"S0022215109005052_ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860280101026"},{"key":"S0022215109005052_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685642"},{"key":"S0022215109005052_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140505"},{"key":"S0022215109005052_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80089-3"},{"key":"S0022215109005052_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1996)9:4<244::AID-CA5>3.0.CO;2-E"},{"key":"S0022215109005052_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.04.018"},{"key":"S0022215109005052_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880301)61:5<903::AID-CNCR2820610508>3.0.CO;2-O"},{"key":"S0022215109005052_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00015"},{"key":"S0022215109005052_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900601"},{"key":"S0022215109005052_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199605000-00008"},{"key":"S0022215109005052_ref10","first-page":"628","article-title":"Anatomical studies related to the dissemination of cancer of the larynx","volume":"64","author":"Pressman","year":"1960","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"S0022215109005052_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600502"},{"key":"S0022215109005052_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106133242402"},{"key":"S0022215109005052_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20715"},{"key":"S0022215109005052_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(97)00092-8"},{"key":"S0022215109005052_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.8.948"},{"key":"S0022215109005052_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031317"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215109005052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:24:06Z","timestamp":1556648646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215109005052\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":17,"journal-issue":{"issue":"S31","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022215109005052"],"URL":"https:\/\/doi.org\/10.1017\/s0022215109005052","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}