{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:19:05Z","timestamp":1759335545571},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"S31","license":[{"start":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T00:00:00Z","timestamp":1242950400000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215109005076_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>Double-probe, 24-hour pH monitoring remains the \u2018gold standard\u2019 for the diagnosis of laryngopharyngeal reflux disease, even though there is no consensus on how to interpret the data collected.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005076_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Tetra-probe, 24-hour pH monitoring was performed in 56 patients with suspected laryngopharyngeal reflux, in order to investigate patterns of laryngopharyngeal and gastroesophageal reflux.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005076_sec3\"><jats:title>Results:<\/jats:title><jats:p>The number of reflux episodes and the total and percentage time periods spent with pH\u00a0&lt;\u00a04.0 were correlated with the distance of the probe from the lower oesophageal sphincter. The number of reflux episodes and the total and percentage time periods with pH\u00a0&lt;\u00a04.0 were greater when patients were upright (i.e. during the daytime). There were few laryngopharyngeal reflux events recorded for pH levels of &lt;4.0; however, there were a significant number of laryngopharyngeal reflux events recorded for pH levels of &lt;5.0, a level capable of causing laryngopharyngeal reflux disease. When a pH level of &lt;5.0 was used, the number, total time and percentage time of laryngopharyngeal reflux episodes was greater during the supine period (i.e. during sleeping) in a quarter of the cases, compared with results when a pH of &lt;4.0 was used.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005076_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>It is valid to use a pH level of 5.0 as indicative of laryngopharyngeal reflux in the hypopharynx.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215109005076","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T10:14:31Z","timestamp":1242987271000},"page":"42-47","source":"Crossref","is-referenced-by-count":9,"title":["Patterns of laryngopharyngeal and gastroesophageal reflux"],"prefix":"10.1017","volume":"123","author":[{"given":"K","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Umeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chitose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"S0022215109005076_ref1","first-page":"2","article-title":"Laryngopharyngeal reflux 2002: a new paradigm of airway disease","volume":"81","author":"Koufman","year":"2002","journal-title":"ENT J"},{"key":"S0022215109005076_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001203"},{"key":"S0022215109005076_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1991.101.s53.1"},{"key":"S0022215109005076_ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.125760"},{"key":"S0022215109005076_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0003489400109S1003"},{"key":"S0022215109005076_ref4","first-page":"14","article-title":"Laryngopharyngeal reflux testing","volume":"81","author":"Postma","year":"2002","journal-title":"ENT J"},{"key":"S0022215109005076_ref5","doi-asserted-by":"publisher","DOI":"10.2468\/jbes.55.9"},{"key":"S0022215109005076_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800780816"},{"key":"S0022215109005076_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199802000-00027"},{"key":"S0022215109005076_ref10","first-page":"25","article-title":"Normal and abnormal proximal esophageal acid exposure. Results of ambulatory dual-probe pH monitoring","volume":"88","author":"Dobhan","year":"1993","journal-title":"Am J Gastroenterol"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215109005076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:24:23Z","timestamp":1556648663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215109005076\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":10,"journal-issue":{"issue":"S31","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0022215109005076"],"URL":"https:\/\/doi.org\/10.1017\/s0022215109005076","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}