{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T09:10:41Z","timestamp":1685005841133},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"S31","license":[{"start":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T00:00:00Z","timestamp":1242950400000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215109005106_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>This study aimed to clarify the significance of cluster of differentiation 9 glycoprotein gene expression in human parotid gland tumours.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005106_sec2\"><jats:title>Methods:<\/jats:title><jats:p>We retrospectively analysed immunohistochemical staining for cluster of differentiation 9 glycoprotein in parotid gland tumours.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005106_sec3\"><jats:title>Results:<\/jats:title><jats:p>Cluster of differentiation 9 glycoprotein was consistently detected in the normal parotid gland. Regarding benign parotid gland tumours, cluster of differentiation 9 glycoprotein was present in 13 of 18 pleomorphic adenomas, in all Warthin tumours tested (21\/21) and in all cases of basal cell adenoma tested (four of four). In contrast, positive staining for cluster of differentiation 9 glycoprotein was less often observed in malignant parotid tumours. Cluster of differentiation 9 glycoprotein was present in 11 of 14 mucoepidermoid carcinomas, in two of five acinic cell carcinomas and in two of five adenoid cystic carcinomas.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215109005106_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>There was a statistically significantly reduced expression of cluster of differentiation 9 glycoprotein in malignant parotid gland tumours, compared with benign parotid gland tumours (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). These results suggest that a low level of cluster of differentiation 9 glycoprotein expression in parotid gland tumours may be associated with malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215109005106","type":"journal-article","created":{"date-parts":[[2009,5,22]],"date-time":"2009-05-22T10:14:31Z","timestamp":1242987271000},"page":"58-63","source":"Crossref","is-referenced-by-count":0,"title":["Expression of cluster of differentiation 9 glycoprotein in benign and malignant parotid gland tumours"],"prefix":"10.1017","volume":"123","author":[{"given":"K","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,22]]},"reference":[{"key":"S0022215109005106_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540107"},{"key":"S0022215109005106_ref10","first-page":"1244","article-title":"Motility-related protein-1 (MRP-1\/CD9) reduction as a factor of poor prognosis in breast cancer","volume":"56","author":"Miyake","year":"1996","journal-title":"Cancer Res"},{"key":"S0022215109005106_ref5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.5.929"},{"key":"S0022215109005106_ref20","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300202.x"},{"key":"S0022215109005106_ref9","first-page":"6040","article-title":"Reduced motility related protein-1 (MRP-1\/CD9) gene expression as a factor of poor prognosis in non-small cell lung cancer","volume":"55","author":"Higashiyama","year":"1995","journal-title":"Cancer Res"},{"key":"S0022215109005106_ref16","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754374"},{"key":"S0022215109005106_ref7","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.4049\/jimmunol.152.6.2768","article-title":"CD9-regulated adhesion. 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