{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:34:21Z","timestamp":1771000461506,"version":"3.50.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221510999048X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Hearing sensitivity usually diminishes with noise exposure. In the present study, we examined the effect of 93\u00a0dB(A) wide band noise on cochlear micromechanical sensitivity in awake guinea pigs.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510999048X_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Animals were randomly assigned to groups receiving either single or repeated noise exposure. Distortion product otoacoustic emission amplitudes were recorded before, during and after noise exposure.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510999048X_sec3\"><jats:title>Results:<\/jats:title><jats:p>Ninety-three decibel(A) wide band noise reduced the distortion product otoacoustic emission amplitudes at all tested frequencies. The distortion product otoacoustic emission amplitudes for higher frequencies showed a permanent reduction, whereas those for lower frequencies showed a temporary reduction. Distortion product otoacoustic emission amplitudes for middle frequencies showed prolonged enhancement after repeated noise exposure.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510999048X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Our results suggest that (1) it is likely that there are intermediate stages between permanent threshold shift and temporary threshold shift, and (2) long-term enhancement of distortion product otoacoustic emission amplitudes may be an indication of tinnitus generation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221510999048x","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T12:28:41Z","timestamp":1247747321000},"page":"1090-1096","source":"Crossref","is-referenced-by-count":4,"title":["Paradoxical long-term enhancement of distortion product otoacoustic emission amplitude after repeated exposure to moderate level, wide band noise in awake guinea pigs"],"prefix":"10.1017","volume":"123","author":[{"given":"L","family":"Mei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z-W","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z-Z","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,7,16]]},"reference":[{"key":"S002221510999048X_ref28","first-page":"51","volume-title":"Proceedings of the Sixth International Tinnitus Seminar","author":"Henry","year":"1999"},{"key":"S002221510999048X_ref11","first-page":"189","volume-title":"New Perspectives in Noise-Induced Hearing Loss","author":"Kemp","year":"1982"},{"key":"S002221510999048X_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895358"},{"key":"S002221510999048X_ref17","first-page":"354","article-title":"Increased otoacoustic-emission amplitude secondary to cochlear lesions","volume":"27","author":"Raveh","year":"1998","journal-title":"J Otolaryngol"},{"key":"S002221510999048X_ref9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00959.2004"},{"key":"S002221510999048X_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(96)00083-4"},{"key":"S002221510999048X_ref19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0042-1748061","article-title":"Cisplatin ototoxicity, increased DPOAE amplitudes, and magnesium deficiency. 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