{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:53:54Z","timestamp":1792058034156,"version":"4.4.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T00:00:00Z","timestamp":1266451200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110000241_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>To review the current literature on the use of sodium fluoride in the treatment of otosclerosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000241_sec2\"><jats:title>Design:<\/jats:title><jats:p>A literature review was conducted, searching the Medline and PubMed database from 1966 to 2009, using the terms \u2018otosclerosis\u2019 and \u2018fluoride\u2019. Article abstracts were reviewed and relevant full articles acquired.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000241_sec3\"><jats:title>Results:<\/jats:title><jats:p>There has been only one double-blind, placebo-controlled trial of the use of sodium fluoride in otosclerosis patients, and this found a reduced incidence of deterioration in hearing after two years in the treatment group. Several case\u2013control series have described a hearing benefit in the sodium fluoride treated group. Treatment doses vary greatly, and there is no evidence regarding the optimum duration of treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000241_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>There is low quality evidence suggesting that sodium fluoride may be of benefit to preserve hearing and reduce vestibular symptoms in patients with otosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110000241","type":"journal-article","created":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T10:20:17Z","timestamp":1266488417000},"page":"583-586","source":"Crossref","is-referenced-by-count":12,"title":["Sodium fluoride in otosclerosis treatment: review"],"prefix":"10.1017","volume":"124","author":[{"given":"A S","family":"Cruise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R E","family":"Quiney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"S0022215110000241_ref16","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137918"},{"key":"S0022215110000241_ref18","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197812000-00004"},{"key":"S0022215110000241_ref15","unstructured":"15 e-Digest Statistics about: Inland Water Quality and Use. 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Early detection, medical management, and prevention","volume":"5","author":"Causse","year":"1984","journal-title":"Am J Otol"},{"key":"S0022215110000241_ref10","first-page":"33","article-title":"The use of electro-acoustic impedance measurements in detecting early clinical otosclerosis","volume":"5","author":"Van Wagoner","year":"1976","journal-title":"J Otolaryngol"},{"key":"S0022215110000241_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1992.tb01004.x"},{"key":"S0022215110000241_ref5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/000164801300043361","article-title":"Fluoride therapy for cochlear otosclerosis? An audiometric and computerized tomography evaluation","volume":"121","author":"Derks","year":"2001","journal-title":"Acta Otolaryngol"},{"key":"S0022215110000241_ref2","first-page":"297","article-title":"The enzymatic mechanism of the otospongiotic disease and NaF action on the enzymatic balance","volume":"3","author":"Causse","year":"1982","journal-title":"Am J Otol"},{"key":"S0022215110000241_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400201"},{"key":"S0022215110000241_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900425"},{"key":"S0022215110000241_ref14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1288\/00005537-198009000-00009","article-title":"Otosclerosis and vestibular dysfunction","volume":"90","author":"Freeman","year":"1980","journal-title":"Laryngoscope"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110000241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T03:47:59Z","timestamp":1711252079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110000241\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,18]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0022215110000241"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110000241","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,18]]}}}