{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:24:20Z","timestamp":1777926260030,"version":"3.51.4"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T00:00:00Z","timestamp":1269302400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110000551_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To consolidate the key features of carcinoma showing thymus-like element, including its management.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000551_sec2\"><jats:title>Method:<\/jats:title><jats:p>We present our experience of the difficult diagnosis and management of this rare tumour. We also present the results of an extensive literature search, documenting those aspects of the clinical picture, natural history and management of carcinoma showing thymus-like element which are relevant to head and neck surgeons.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000551_sec3\"><jats:title>Result:<\/jats:title><jats:p>Intrathyroidal, epithelial carcinoma showing thymus-like element is a rare, malignant tumour of the thyroid gland, with histopathological features similar to squamous cell carcinoma but a more favourable prognosis. It is usually treated surgically using a combination of total thyroidectomy and selective neck dissection, with radiotherapy and chemotherapy in selected cases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000551_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Carcinoma showing thymus-like element of the thyroid gland is a rare condition. Head and neck surgeons with a thyroid interest should be aware of this tumour, because of its close histological resemblance to other, commoner malignancies of the thyroid gland.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110000551","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T09:48:19Z","timestamp":1269337699000},"page":"1242-1244","source":"Crossref","is-referenced-by-count":2,"title":["Management of carcinoma showing thymus-like element"],"prefix":"10.1017","volume":"124","author":[{"given":"D","family":"Biswas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Karsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,3,23]]},"reference":[{"key":"S0022215110000551_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.09.016"},{"key":"S0022215110000551_ref9","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.1383"},{"key":"S0022215110000551_ref2","first-page":"1013","volume-title":"Diagnostic Histopathology of Tumors","author":"Chan","year":"2000"},{"key":"S0022215110000551_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90083-2"},{"key":"S0022215110000551_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/106689690601400214"},{"key":"S0022215110000551_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4510"},{"key":"S0022215110000551_ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00318.x"},{"key":"S0022215110000551_ref4","doi-asserted-by":"publisher","DOI":"10.1309\/VM7E52B6U9Q729DQ"},{"key":"S0022215110000551_ref6","first-page":"303","article-title":"Thyroid squamous-cell carcinoma showing thymus-like element (CASTLE): a report of eight cases [in Chinese]","volume":"21","author":"Da","year":"1999","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"S0022215110000551_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199609)15:3<224::AID-DC9>3.0.CO;2-G"},{"key":"S0022215110000551_ref5","first-page":"1225","article-title":"Carcinoma showing thymic like differentiation (CASTLE tumor)","volume":"19","author":"Ahuja","year":"1998","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0022215110000551_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90461-X"},{"key":"S0022215110000551_ref15","first-page":"419","volume-title":"Thyroid Cytopathology: An Atlas and Text","author":"Kini","year":"2008"},{"key":"S0022215110000551_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20237"},{"key":"S0022215110000551_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01656263"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110000551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T21:04:37Z","timestamp":1556399077000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110000551\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,23]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0022215110000551"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110000551","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,23]]}}}