{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:04:41Z","timestamp":1771657481621,"version":"3.50.1"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T00:00:00Z","timestamp":1271203200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110000678_sec1\"><jats:title>Introduction:<\/jats:title><jats:p>A patients with undiagnosed type II diabetes mellitus presented with infective rhinocerebral mucormycosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000678_sec2\"><jats:title>Investigation results:<\/jats:title><jats:p>Initial magnetic resonance imaging scans demonstrated an aggressive disease process involving the left orbit and paranasal sinuses. A repeated scan following treatment excluded intracranial spread or recurrence. Pus from the paranasal sinuses grew <jats:italic>Rhizopus arrhizus<\/jats:italic> on microbiological culture.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000678_sec3\"><jats:title>Management:<\/jats:title><jats:p>Initial treatment comprised intravenous liposomal amphotericin B, intravenous co-amoxiclav and surgical debridement. The patient's diabetes was managed medically. The development of drug-induced transaminitis required a change of medication. The dose of liposomal amphotericin B was reduced, and then titrated back up as the liver function test results improved. Posaconazole was also introduced and the patient was eventually discharged on this alone, as the maximum recommended cumulative dose of liposomal amphotericin B had been reached.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000678_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>Posaconazole may be used effectively in conjunction with surgical debridement in the treatment of patients with infective rhinocerebral mucormycosis who develop hepatotoxic side effects to liposomal amphotericin B. Posaconazole may also allow a reduction in the dose of liposomal amphotericin B, resulting in better tolerance.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110000678","type":"journal-article","created":{"date-parts":[[2010,4,14]],"date-time":"2010-04-14T06:14:24Z","timestamp":1271225664000},"page":"1314-1317","source":"Crossref","is-referenced-by-count":7,"title":["Use of posaconazole in the treatment of infective rhinocerebral mucormycosis"],"prefix":"10.1017","volume":"124","author":[{"given":"K","family":"Kulendra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Habibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,4,14]]},"reference":[{"key":"S0022215110000678_ref17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.658-666.2006"},{"key":"S0022215110000678_ref14","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910800218"},{"key":"S0022215110000678_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0919-0"},{"key":"S0022215110000678_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200412000-00003"},{"key":"S0022215110000678_ref15","doi-asserted-by":"publisher","DOI":"10.1086\/516353"},{"key":"S0022215110000678_ref6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.126-133.2006"},{"key":"S0022215110000678_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440030145018"},{"key":"S0022215110000678_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110031005"},{"key":"S0022215110000678_ref2","doi-asserted-by":"publisher","DOI":"10.1201\/b15118-23"},{"key":"S0022215110000678_ref16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00163-06"},{"key":"S0022215110000678_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199707000-00004"},{"key":"S0022215110000678_ref7","first-page":"376","article-title":"Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases","volume":"43","author":"Van Burik","year":"2006","journal-title":"Clin Infect Dis"},{"key":"S0022215110000678_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-200295040-00016"},{"key":"S0022215110000678_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/313803"},{"key":"S0022215110000678_ref18","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01124-08"},{"key":"S0022215110000678_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00628-08"},{"key":"S0022215110000678_ref9","unstructured":"9 AmBisome. 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