{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:17:24Z","timestamp":1759515444230},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T00:00:00Z","timestamp":1273017600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110000770_sec1\"><jats:title>Objective:<\/jats:title><jats:p>We report a rare case of avascular necrosis of the maxilla secondary to oral bisphosphonates.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000770_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Case report and review of the world literature concerning avascular necrosis as a result of bisphosphonate therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000770_sec3\"><jats:title>Case report:<\/jats:title><jats:p>A 62-year-old woman presented with unilateral nasal obstruction, swelling of the cheek and an ulcerating lesion of the upper alveolus. She had a past medical history of osteoporosis, for which she took oral bisphosphonates. Investigation revealed necrosis of the maxilla, and avascular necrosis secondary to oral bisphosphonates was diagnosed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110000770_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>There have been several documented cases of avascular necrosis of the mandible and maxilla following intravenous bisphosphonates or dental procedures. In our case, bisphosphonates were only taken orally and no dental work had been undertaken. This patient's clinical presentation was highly suggestive of malignancy, and we would like to communicate this unusual case to other otolaryngologists.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110000770","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T08:49:51Z","timestamp":1273049391000},"page":"1318-1320","source":"Crossref","is-referenced-by-count":2,"title":["Case of maxillary avascular necrosis due to oral bisphosphonates, presenting with signs of malignancy"],"prefix":"10.1017","volume":"124","author":[{"given":"R","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Blackmore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,5,5]]},"reference":[{"key":"S0022215110000770_ref8","first-page":"94","article-title":"Bisphosphonates and avascular necrosis of the mandible: case report and review of the literature","volume":"61","author":"Murray","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"S0022215110000770_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802633"},{"key":"S0022215110000770_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"S0022215110000770_ref9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00341.x"},{"key":"S0022215110000770_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(83)90294-X"},{"key":"S0022215110000770_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00269.x"},{"key":"S0022215110000770_ref3","unstructured":"3 Joint Formulary Committee. British National Formulary. 56th edition. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2008"},{"key":"S0022215110000770_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000187398.51857.3c"},{"key":"S0022215110000770_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000240885.64568.9e"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110000770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T20:45:31Z","timestamp":1556397931000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110000770\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,5]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0022215110000770"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110000770","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,5]]}}}