{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:55:13Z","timestamp":1792097713263,"version":"4.4.0"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T00:00:00Z","timestamp":1277337600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110001489_sec1\"><jats:title>Objective:<\/jats:title><jats:p>We report the case of a recurrent familial malignant carotid body tumour presenting with metastasis to local ipsilateral lymph nodes; the rarity of both recurrence combined with nodal spread is emphasised in this article.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001489_sec2\"><jats:title>Method:<\/jats:title><jats:p>We present a case report, and a review of the world literature concerning the diagnosis and management of carotid body tumours in the familial setting.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001489_sec3\"><jats:title>Case report:<\/jats:title><jats:p>A woman with a family history of succinate dehydrogenase complex subunit B gene mutation presented with right vocal fold palsy. A causative carotid body tumour was excised. Fifteen years later, the patient developed a right-sided swelling in the jugulo-digastric region, together with shooting pains towards her right ear. Imaging revealed right posterior triangle lymphadenopathy. Fine needle aspiration cytology of the node was equivocal. Computed tomography of her neck revealed, in addition, a mass within the right side of the larynx. Excision biopsy of the lymph node demonstrated metastatic paraganglioma. A carotid angiogram revealed a right-sided carotid body tumour. This was embolised prior to neck exploration and excision of the carotid body tumour with en bloc resection of adjacent nodes. Histological analysis confirmed the presence of lymph nodes containing metastatic paraganglioma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001489_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This case report demonstrates the need for extra vigilance to enable early disease detection in the familial setting of carotid body tumour, in order to reduce the surgical morbidity associated with disease progression. In addition, our report highlights the atypical aspects of presentation in the familial setting, together with the difficulty and lack of standardisation regarding monitoring of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110001489","type":"journal-article","created":{"date-parts":[[2010,6,24]],"date-time":"2010-06-24T06:02:23Z","timestamp":1277359343000},"page":"1344-1346","source":"Crossref","is-referenced-by-count":7,"title":["Recurrent familial malignant carotid body tumour presenting with lymph node metastasis: case report, and review of diagnosis and management of familial carotid body tumours"],"prefix":"10.1017","volume":"124","author":[{"given":"T C","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Renwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N D","family":"Stafford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,6,24]]},"reference":[{"key":"S0022215110001489_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800730107"},{"key":"S0022215110001489_ref6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/jama.292.8.943","article-title":"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations","volume":"292","author":"Hartmut","year":"2004","journal-title":"J Am Med Assoc"},{"key":"S0022215110001489_ref3","first-page":"365","article-title":"Carotid body tumours","volume":"80","author":"Dent","year":"1976","journal-title":"Surgery"},{"key":"S0022215110001489_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-001-0106-8"},{"key":"S0022215110001489_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060010075018"},{"key":"S0022215110001489_ref4","first-page":"1109","article-title":"Paraganglioma of the neck. Analysis of 32 operated cases [in Italian]","volume":"46","author":"Ghilardi","year":"1991","journal-title":"Minerva Chir"},{"key":"S0022215110001489_ref8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/014556130208100814","article-title":"Temporary balloon occlusion and ethanol injection for preoperative embolisation of carotid-body tumour","volume":"81","author":"Horowitz","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"S0022215110001489_ref7","first-page":"1929","article-title":"Recurrent malignant carotid body tumour: report of one case and review of the literature","volume":"118","author":"Zheng","year":"2005","journal-title":"Chin Med J"},{"key":"S0022215110001489_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(87)80005-1"},{"key":"S0022215110001489_ref11","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1017\/S0022215107000023","article-title":"Familial carotid body tumours: is there a role for genetic screening?","volume":"122","author":"Jani","year":"2008","journal-title":"J Larygol Otol"},{"key":"S0022215110001489_ref10","first-page":"77","article-title":"Slowly growing pulmonary metastases of malignant cervical chemodectomas","volume":"34","author":"Voorda","year":"1994","journal-title":"Acta Oncol"},{"key":"S0022215110001489_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801101)46:9<2116::AID-CNCR2820460934>3.0.CO;2-S"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110001489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T07:16:46Z","timestamp":1559200606000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110001489\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,24]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0022215110001489"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110001489","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,24]]}}}