{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:47:56Z","timestamp":1761662876912},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T00:00:00Z","timestamp":1278374400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110001568_sec1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to review cases of Lemierre's and Lemierre's-like syndromes in paediatric patients, to examine a possible association with Epstein\u2013Barr virus as a predisposing factor, and to assess the impact of this virus on the severity of illness.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001568_sec2\"><jats:title>Methods:<\/jats:title><jats:p>We performed a retrospective analysis of data from the in-patient database at Winthrop University Hospital, from January 2001 to October 2007. We reviewed clinical and laboratory findings as well as the outcome of infection in patients aged 21 years or less with a diagnosis of Lemierre's syndrome. An additional case of Lemierre's-like syndrome was also included. The illness severity and duration of in-patient management of those testing positive for heterophile antibody were then compared with the same parameters in patients who tested negative.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001568_sec3\"><jats:title>Results:<\/jats:title><jats:p>Of the five patients diagnosed with Lemierre's syndrome, two had concomitant acute infection with Epstein\u2013Barr virus. Additionally, a 19-year-old adolescent was admitted during this period with acute infectious mononucleosis, <jats:italic>Fusobacterium necrophorum<\/jats:italic> sepsis, sinusitis, frontal lobe abscess and ophthalmic vein thrombosis. The clinical presentation of all patients included fever, sore throat, and ear or neck pain. The duration of symptoms ranged from two days to three weeks prior to admission. The patients with acute Epstein\u2013Barr virus infection had been diagnosed with infectious mononucleosis prior to admission, and tested positive for heterophile antibody. These patients subsequently underwent more extensive in-patient treatment, including intensive care management and ventilator support. The patients who tested negative for heterophile antibody experienced a milder course of illness, with a shorter duration of in-patient management.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110001568_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Two patients diagnosed with Lemierre's syndrome, and a third with <jats:italic>Fusobacterium necrophorum<\/jats:italic> sepsis, had coexisting acute Epstein\u2013Barr virus infection. Patients who tested positive for heterophile antibody experienced a more severe course of illness. These observations suggest a possible association between Epstein\u2013Barr virus infection and the severity of concomitant Lemierre's syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110001568","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T08:45:24Z","timestamp":1278405924000},"page":"1257-1262","source":"Crossref","is-referenced-by-count":25,"title":["Lemierre's and Lemierre's-like syndromes in association with infectious mononucleosis"],"prefix":"10.1017","volume":"124","author":[{"given":"E M","family":"Chacko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L R","family":"Krilov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Patten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,7,6]]},"reference":[{"key":"S0022215110001568_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.10.043"},{"key":"S0022215110001568_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2004.12.003"},{"key":"S0022215110001568_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.10.016"},{"key":"S0022215110001568_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000091374.54304.7c"},{"key":"S0022215110001568_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340010021020"},{"key":"S0022215110001568_ref9","first-page":"286","volume-title":"Red Book: 2006 Report of the Committee on Infectious Disease","author":"Pickering","year":"2006"},{"key":"S0022215110001568_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-07"},{"key":"S0022215110001568_ref5","unstructured":"5 Mononucleosis and EBV. In: http:\/\/www.emedicine.medscape.com\/article\/963894-overview [4 October 2007]"},{"key":"S0022215110001568_ref2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3445-3448.2003"},{"key":"S0022215110001568_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)57035-4"},{"key":"S0022215110001568_ref4","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.2.659-661.2006"},{"key":"S0022215110001568_ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0433"},{"key":"S0022215110001568_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16601-4"},{"key":"S0022215110001568_ref6","unstructured":"6 Epstein-Barr virus and Infectious Mononucleosis. 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